ID   DJC27_CHICK             Reviewed;         273 AA.
AC   Q6IMM1;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=DnaJ homolog subfamily C member 27;
DE   AltName: Full=Rab and DnaJ domain-containing protein;
GN   Name=DNAJC27; Synonyms=RBJ;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=White leghorn; TISSUE=Embryonic gonad;
RX   PubMed=16939661; DOI=10.1186/1471-2164-7-220;
RA   Han J.Y., Park T.S., Kim J.N., Kim M.A., Lim D., Lim J.M., Kim H.;
RT   "Gene expression profiling of chicken primordial germ cell ESTs.";
RL   BMC Genomics 7:220-220(2006).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=14980719; DOI=10.1016/j.gene.2003.11.010;
RA   Nepomuceno-Silva J.L., de Melo L.D., Mendonca S.M., Paixao J.C.,
RA   Lopes U.G.;
RT   "RJLs: a new family of Ras-related GTP-binding proteins.";
RL   Gene 327:221-232(2004).
CC   -!- FUNCTION: GTPase possibly involved in regulation of the MEK/ERK
CC       pathway. {ECO:0000250|UniProtKB:Q8CFP6}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8CFP6}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC       {ECO:0000305}.
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DR   EMBL; DR414424; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BK001282; DAA01321.1; -; mRNA.
DR   RefSeq; NP_998723.1; NM_213558.1.
DR   AlphaFoldDB; Q6IMM1; -.
DR   SMR; Q6IMM1; -.
DR   STRING; 9031.ENSGALP00000041528; -.
DR   PaxDb; Q6IMM1; -.
DR   Ensembl; ENSGALT00000045362; ENSGALP00000041528; ENSGALG00000028967.
DR   GeneID; 402783; -.
DR   KEGG; gga:402783; -.
DR   CTD; 51277; -.
DR   VEuPathDB; HostDB:geneid_402783; -.
DR   eggNOG; KOG0098; Eukaryota.
DR   GeneTree; ENSGT00940000157133; -.
DR   HOGENOM; CLU_041217_16_0_1; -.
DR   InParanoid; Q6IMM1; -.
DR   OMA; MGNAETG; -.
DR   OrthoDB; 1288652at2759; -.
DR   PhylomeDB; Q6IMM1; -.
DR   TreeFam; TF328564; -.
DR   PRO; PR:Q6IMM1; -.
DR   Proteomes; UP000000539; Chromosome 3.
DR   Bgee; ENSGALG00000028967; Expressed in brain and 13 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
DR   GO; GO:0071701; P:regulation of MAPK export from nucleus; IEA:Ensembl.
DR   CDD; cd06257; DnaJ; 1.
DR   Gene3D; 1.10.287.110; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR001623; DnaJ_domain.
DR   InterPro; IPR036869; J_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   Pfam; PF00226; DnaJ; 1.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00625; JDOMAIN.
DR   SMART; SM00271; DnaJ; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF46565; SSF46565; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS50076; DNAJ_2; 1.
DR   PROSITE; PS51419; RAB; 1.
PE   2: Evidence at transcript level;
KW   GTP-binding; Nucleotide-binding; Nucleus; Reference proteome.
FT   CHAIN           1..273
FT                   /note="DnaJ homolog subfamily C member 27"
FT                   /id="PRO_0000332979"
FT   DOMAIN          217..273
FT                   /note="J"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT   BINDING         23..30
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         71..75
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         134..137
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   273 AA;  30778 MW;  DAC0C200E9D6E3A8 CRC64;
     MEANAPKRKE ARKSLRIKVI SMGNAEVGKS CIIKRYCEKR FVPKYLATIG IDYGVTKVQV
     RDREIKVNIF DMAGHPFFYE VRNEFYKDTQ GVILVYDVGQ KESFDALDAW LAEMKQELGP
     HGNMDNIVFV VCANKIDCTK HRSVDESEGR LWAESRGFLY FETSAQTGEG INEMFQTFYS
     AIIDLCDNGG KRPPSSMGVG FTKEQADAIR RIRNSKDSWD MLGVKPGATR DEVNKAYRKL
     AVLLHPDKCV APGSEDAFKA VVNARTALLK NIK