ID   DJC27_DANRE             Reviewed;         273 AA.
AC   Q6IMK3;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=DnaJ homolog subfamily C member 27;
DE   AltName: Full=Rab and DnaJ domain-containing protein;
GN   Name=dnajc27; Synonyms=rbj;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=14980719; DOI=10.1016/j.gene.2003.11.010;
RA   Nepomuceno-Silva J.L., de Melo L.D., Mendonca S.M., Paixao J.C.,
RA   Lopes U.G.;
RT   "RJLs: a new family of Ras-related GTP-binding proteins.";
RL   Gene 327:221-232(2004).
CC   -!- FUNCTION: GTPase possibly involved in regulation of the MEK/ERK
CC       pathway. {ECO:0000250|UniProtKB:Q8CFP6}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8CFP6}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC       {ECO:0000305}.
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DR   EMBL; BX323819; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BK001388; DAA01381.1; -; mRNA.
DR   RefSeq; NP_001007163.1; NM_001007162.2.
DR   AlphaFoldDB; Q6IMK3; -.
DR   SMR; Q6IMK3; -.
DR   STRING; 7955.ENSDARP00000109834; -.
DR   PaxDb; Q6IMK3; -.
DR   Ensembl; ENSDART00000154580; ENSDARP00000127972; ENSDARG00000070916.
DR   GeneID; 402784; -.
DR   KEGG; dre:402784; -.
DR   CTD; 51277; -.
DR   ZFIN; ZDB-GENE-081022-93; dnajc27.
DR   eggNOG; KOG0098; Eukaryota.
DR   GeneTree; ENSGT00940000157133; -.
DR   HOGENOM; CLU_041217_16_0_1; -.
DR   InParanoid; Q6IMK3; -.
DR   PhylomeDB; Q6IMK3; -.
DR   PRO; PR:Q6IMK3; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 17.
DR   Bgee; ENSDARG00000070916; Expressed in mature ovarian follicle and 23 other tissues.
DR   ExpressionAtlas; Q6IMK3; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   CDD; cd06257; DnaJ; 1.
DR   Gene3D; 1.10.287.110; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR001623; DnaJ_domain.
DR   InterPro; IPR036869; J_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   Pfam; PF00226; DnaJ; 1.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00625; JDOMAIN.
DR   SMART; SM00271; DnaJ; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF46565; SSF46565; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS50076; DNAJ_2; 1.
DR   PROSITE; PS51419; RAB; 1.
PE   2: Evidence at transcript level;
KW   GTP-binding; Nucleotide-binding; Nucleus; Reference proteome.
FT   CHAIN           1..273
FT                   /note="DnaJ homolog subfamily C member 27"
FT                   /id="PRO_0000332980"
FT   DOMAIN          217..273
FT                   /note="J"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT   BINDING         23..30
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         71..75
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         134..137
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   273 AA;  31108 MW;  178F9AF05C4CB5AD CRC64;
     MDTNVQKRRE NKKSLRVKVI SLGNAEVGKS CIIKRYCEKR FVPKYLATIG IDYGVTKVQV
     RDREIKVNIF DMAGHPFFYE VRNEFYKDSQ GVILVYDVGL RESFDALDSW LTEMKQEMGS
     QANMENIIFV VCANKVDLTK RRVVDESEGR LWAESRGFHY FETSAQSGEG INEMFQSFFS
     SITDMCENGG KRPTPEVSVG FTKEQADTIR RIRNSKDSWD MLGVKPGATR EEVNKAYRKL
     AVLLHPDKCV APGSEDAFKA VVNARTSLLK NIK