ID   DKK4_MOUSE              Reviewed;         221 AA.
AC   Q8VEJ3;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Dickkopf-related protein 4;
DE            Short=Dickkopf-4;
DE            Short=Dkk-4;
DE   Flags: Precursor;
GN   Name=Dkk4;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Czech II; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   REVIEW OF THE DKK FAMILY.
RX   PubMed=17143291; DOI=10.1038/sj.onc.1210054;
RA   Niehrs C.;
RT   "Function and biological roles of the Dickkopf family of Wnt modulators.";
RL   Oncogene 25:7469-7481(2006).
CC   -!- FUNCTION: Antagonizes canonical Wnt signaling by inhibiting LRP5/6
CC       interaction with Wnt and by forming a ternary complex with the
CC       transmembrane protein KREMEN that promotes internalization of LRP5/6.
CC       DKKs play an important role in vertebrate development, where they
CC       locally inhibit Wnt regulated processes such as antero-posterior axial
CC       patterning, limb development, somitogenesis and eye formation. In the
CC       adult, Dkks are implicated in bone formation and bone disease, cancer
CC       and Alzheimer disease (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with LRP5 and LRP6. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- DOMAIN: The C-terminal cysteine-rich domain mediates interaction with
CC       LRP5 and LRP6. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the dickkopf family. {ECO:0000305}.
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DR   EMBL; BC018400; AAH18400.1; -; mRNA.
DR   CCDS; CCDS22180.1; -.
DR   RefSeq; NP_663567.1; NM_145592.2.
DR   RefSeq; XP_006509161.1; XM_006509098.2.
DR   AlphaFoldDB; Q8VEJ3; -.
DR   SMR; Q8VEJ3; -.
DR   STRING; 10090.ENSMUSP00000033936; -.
DR   iPTMnet; Q8VEJ3; -.
DR   PhosphoSitePlus; Q8VEJ3; -.
DR   PaxDb; Q8VEJ3; -.
DR   PRIDE; Q8VEJ3; -.
DR   Antibodypedia; 24127; 414 antibodies from 33 providers.
DR   DNASU; 234130; -.
DR   Ensembl; ENSMUST00000033936; ENSMUSP00000033936; ENSMUSG00000031535.
DR   GeneID; 234130; -.
DR   KEGG; mmu:234130; -.
DR   UCSC; uc009ldj.1; mouse.
DR   CTD; 27121; -.
DR   MGI; MGI:2385299; Dkk4.
DR   VEuPathDB; HostDB:ENSMUSG00000031535; -.
DR   eggNOG; KOG1218; Eukaryota.
DR   GeneTree; ENSGT00940000161614; -.
DR   HOGENOM; CLU_080459_1_0_1; -.
DR   InParanoid; Q8VEJ3; -.
DR   OMA; RKFCLQP; -.
DR   OrthoDB; 1139517at2759; -.
DR   PhylomeDB; Q8VEJ3; -.
DR   TreeFam; TF330916; -.
DR   Reactome; R-MMU-3772470; Negative regulation of TCF-dependent signaling by WNT ligand antagonists.
DR   BioGRID-ORCS; 234130; 2 hits in 73 CRISPR screens.
DR   ChiTaRS; Dkk4; mouse.
DR   PRO; PR:Q8VEJ3; -.
DR   Proteomes; UP000000589; Chromosome 8.
DR   RNAct; Q8VEJ3; protein.
DR   Bgee; ENSMUSG00000031535; Expressed in renal cortex interstitium and 56 other tissues.
DR   Genevisible; Q8VEJ3; MM.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0039706; F:co-receptor binding; IBA:GO_Central.
DR   GO; GO:0048019; F:receptor antagonist activity; IBA:GO_Central.
DR   GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IBA:GO_Central.
DR   GO; GO:0061170; P:negative regulation of hair follicle placode formation; IDA:MGI.
DR   GO; GO:0016055; P:Wnt signaling pathway; IDA:MGI.
DR   InterPro; IPR006796; Dickkopf_N.
DR   InterPro; IPR039863; DKK-like.
DR   InterPro; IPR023569; Prokineticin_domain.
DR   PANTHER; PTHR12113; PTHR12113; 1.
DR   Pfam; PF04706; Dickkopf_N; 1.
DR   Pfam; PF06607; Prokineticin; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Disulfide bond; Reference proteome; Secreted;
KW   Signal; Wnt signaling pathway.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..221
FT                   /note="Dickkopf-related protein 4"
FT                   /id="PRO_0000007227"
FT   REGION          41..90
FT                   /note="DKK-type Cys-1"
FT   REGION          101..143
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          145..218
FT                   /note="DKK-type Cys-2"
FT   COMPBIAS        129..143
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        145..157
FT                   /evidence="ECO:0000250"
FT   DISULFID        151..166
FT                   /evidence="ECO:0000250"
FT   DISULFID        156..194
FT                   /evidence="ECO:0000250"
FT   DISULFID        176..202
FT                   /evidence="ECO:0000250"
FT   DISULFID        196..218
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   221 AA;  24261 MW;  670AD9F750BF1715 CRC64;
     MVLVTLLGLS WFCSPLAALV LDFNNIKSSA DVQGAGKGSL CASDRDCSEG KFCLAFHDER
     SFCATCRRVR RRCQRSAVCC PGTVCVNDVC TAVEDTRPVM DRNTDGQDGA YAEGTTKWPA
     EENRPQGKPS TKKSQSSKGQ EGESCLRTSD CGPGLCCARH FWTKICKPVL REGQVCSRRG
     HKDTAQAPEI FQRCDCGPGL TCRSQVTSNR QHSRLRVCQR I