DKSA_CAUVN
ID DKSA_CAUVN Reviewed; 142 AA.
AC B8H0C0; O32347;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=RNA polymerase-binding transcription factor DksA {ECO:0000255|HAMAP-Rule:MF_00926};
GN Name=dksA {ECO:0000255|HAMAP-Rule:MF_00926}; OrderedLocusNames=CCNA_02663;
OS Caulobacter vibrioides (strain NA1000 / CB15N) (Caulobacter crescentus).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC Caulobacteraceae; Caulobacter.
OX NCBI_TaxID=565050;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9555902; DOI=10.1128/jb.180.8.2175-2185.1998;
RA Mohr C.D., MacKichan J.K., Shapiro L.;
RT "A membrane-associated protein, FliX, is required for an early step in
RT Caulobacter flagellar assembly.";
RL J. Bacteriol. 180:2175-2185(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NA1000 / CB15N;
RX PubMed=20472802; DOI=10.1128/jb.00255-10;
RA Marks M.E., Castro-Rojas C.M., Teiling C., Du L., Kapatral V.,
RA Walunas T.L., Crosson S.;
RT "The genetic basis of laboratory adaptation in Caulobacter crescentus.";
RL J. Bacteriol. 192:3678-3688(2010).
CC -!- FUNCTION: Transcription factor that acts by binding directly to the RNA
CC polymerase (RNAP). Required for negative regulation of rRNA expression
CC and positive regulation of several amino acid biosynthesis promoters.
CC {ECO:0000255|HAMAP-Rule:MF_00926}.
CC -!- SUBUNIT: Interacts directly with the RNA polymerase.
CC {ECO:0000255|HAMAP-Rule:MF_00926}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00926}.
CC -!- SIMILARITY: Belongs to the DksA family. {ECO:0000255|HAMAP-
CC Rule:MF_00926}.
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DR EMBL; AF034413; AAC38353.1; -; Genomic_DNA.
DR EMBL; CP001340; ACL96128.1; -; Genomic_DNA.
DR RefSeq; WP_010920436.1; NC_011916.1.
DR RefSeq; YP_002518036.1; NC_011916.1.
DR AlphaFoldDB; B8H0C0; -.
DR SMR; B8H0C0; -.
DR PRIDE; B8H0C0; -.
DR EnsemblBacteria; ACL96128; ACL96128; CCNA_02663.
DR GeneID; 7332766; -.
DR KEGG; ccs:CCNA_02663; -.
DR PATRIC; fig|565050.3.peg.2611; -.
DR HOGENOM; CLU_043144_2_2_5; -.
DR OMA; KKGEEYM; -.
DR OrthoDB; 1932026at2; -.
DR PhylomeDB; B8H0C0; -.
DR Proteomes; UP000001364; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0010468; P:regulation of gene expression; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00926; DksA; 1.
DR InterPro; IPR012784; DksA_RNA_pol-bd.
DR InterPro; IPR037187; DnaK_N.
DR InterPro; IPR000962; Znf_DskA_TraR.
DR InterPro; IPR020458; Znf_DskA_TraR_CS.
DR Pfam; PF01258; zf-dskA_traR; 1.
DR SUPFAM; SSF109635; SSF109635; 1.
DR TIGRFAMs; TIGR02420; dksA; 1.
DR PROSITE; PS01102; ZF_DKSA_1; 1.
DR PROSITE; PS51128; ZF_DKSA_2; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..142
FT /note="RNA polymerase-binding transcription factor DksA"
FT /id="PRO_0000378283"
FT ZN_FING 104..128
FT /note="dksA C4-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00926"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 51..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 119..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..142
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 137
FT /note="R -> P (in Ref. 1; AAC38353)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 142 AA; 16775 MW; 8824F2DD9827B89C CRC64;
MQTATVLVEK SDYRPSEDEP FMNDRQLEYF KQKLLAWKEE ILRESRETVS HLQKETENHA
DLADRASSET DRALELRTRD RQRKLISKID QALRRVEDGS YGYCEETGEP IGLARLEARP
TATMSVEAQE RHERRERVHR DD
