ID   DLEC1_MOUSE             Reviewed;         635 AA.
AC   Q8BLA1;
DT   25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Deleted in lung and esophageal cancer protein 1 homolog;
GN   Name=Dlec1 {ECO:0000312|MGI:MGI:2443671};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1] {ECO:0000312|EMBL:BAC32510.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J {ECO:0000312|EMBL:BAC32510.1};
RC   TISSUE=Corpora quadrigemina {ECO:0000312|EMBL:BAC32510.1};
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP   STAGE.
RX   PubMed=33144677; DOI=10.1038/s41598-020-75957-y;
RA   Okitsu Y., Nagano M., Yamagata T., Ito C., Toshimori K., Dohra H.,
RA   Fujii W., Yogo K.;
RT   "Dlec1 is required for spermatogenesis and male fertility in mice.";
RL   Sci. Rep. 10:18883-18883(2020).
CC   -!- FUNCTION: Essential for spermatogenesis and male fertility
CC       (PubMed:33144677). May play an important role in sperm head and tail
CC       formation (PubMed:33144677). May act as a tumor suppressor by
CC       inhibiting cell proliferation (By similarity).
CC       {ECO:0000250|UniProtKB:Q9Y238, ECO:0000269|PubMed:33144677}.
CC   -!- SUBUNIT: Interacts with alpha-and beta-tubulin (By similarity).
CC       Interacts with BBS2, BBS4, BBS5, MKKS, TCP1, CCT2, CCT3, CCT4, CCT5 and
CC       CCT7 (By similarity). {ECO:0000250|UniProtKB:Q9Y238}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9Y238}.
CC   -!- TISSUE SPECIFICITY: Expressed in germ cells of the testis (at protein
CC       level) (PubMed:33144677). Also expressed in the lung and kidney
CC       (PubMed:33144677). {ECO:0000269|PubMed:33144677}.
CC   -!- DEVELOPMENTAL STAGE: Expression begins at postnatal day 20 (P20) and
CC       reaches a mximum at P25 in the testis (at protein level).
CC       {ECO:0000269|PubMed:33144677}.
CC   -!- DISRUPTION PHENOTYPE: Male mice are infertile due to impaired
CC       spermatogenesis (PubMed:33144677). Sperms are immotile and show an
CC       abnormal head shape and short flagellum, and are often accompanied by
CC       an abnormal manchette structure (PubMed:33144677).
CC       {ECO:0000269|PubMed:33144677}.
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DR   EMBL; AK045848; BAC32510.1; -; mRNA.
DR   AlphaFoldDB; Q8BLA1; -.
DR   STRING; 10090.ENSMUSP00000122380; -.
DR   PaxDb; Q8BLA1; -.
DR   PRIDE; Q8BLA1; -.
DR   ProteomicsDB; 279720; -.
DR   MGI; MGI:2443671; Dlec1.
DR   eggNOG; ENOG502QQQ5; Eukaryota.
DR   InParanoid; Q8BLA1; -.
DR   PhylomeDB; Q8BLA1; -.
DR   ChiTaRS; Dlec1; mouse.
DR   PRO; PR:Q8BLA1; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; Q8BLA1; protein.
DR   GO; GO:0005929; C:cilium; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; ISO:MGI.
DR   GO; GO:0043014; F:alpha-tubulin binding; ISO:MGI.
DR   GO; GO:0048487; F:beta-tubulin binding; ISO:MGI.
DR   GO; GO:0015631; F:tubulin binding; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0002357; P:defense response to tumor cell; ISO:MGI.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:InterPro.
DR   GO; GO:0007283; P:spermatogenesis; IMP:UniProtKB.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR033304; DLEC1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   PANTHER; PTHR46348; PTHR46348; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Differentiation; Reference proteome; Spermatogenesis;
KW   Tumor suppressor.
FT   CHAIN           1..635
FT                   /note="Deleted in lung and esophageal cancer protein 1
FT                   homolog"
FT                   /id="PRO_0000079930"
SQ   SEQUENCE   635 AA;  71183 MW;  DA683E5B5926A333 CRC64;
     MDSESKEEQQ CTASSAVMSS LETQFLSVPH QLESASLSWS IRKSLHSSTV LMDDCHFGFP
     TRSLRAGFHA LPPLPEPQTL RLRPASLRTQ EISHLLARVF RNLYTAQVIG DDLSDSLIKA
     RGSEDARHEE FLDQLQQARA IYKQRLDEAA MLERHIMQAR ARDIAETEHT TKQSRLQVVE
     TPVKLPPVKT AFRWCLDSKL MRKHHLISTE DYYTDPVPFC PAPKDKSTLG CSKLTFSCEQ
     RFLRKSELDR EAEEHCRQLT ECDDFEYTVD SLGSISKAKE RTTDSVKKTS RPKNKKWMEH
     LQVPQRALDR RLLASMENRN HFLKNPRFFP PNTPHGGKSL IVPLSKPERR ASLNAEPEWS
     CTDAPVFLAK PSVGFFTDYE IGPVYEMVIA LQNTTSTSRF LRVLPPSSPY FALGLGMFPG
     KGGIVAPGMT CQYIVQFIPD CLGDFDDFIL VETQSPHTLV IPLQARRPPP VLTLSPVLDC
     GHCLIGGVKI TKFICKNVGF SVGKFCIMPQ KSWPPPSFRA VATTGFVEQP PFGVMPSVFE
     LAPGYAILLE VLFLPTGLGQ AEETFIIVCD NCQIKEVVVV GTGQLVALDL IHISGGKNEP
     DPGELKDLTA QYFIRFEPEN VQSTPKKQLI IRNAT