ID   DLEC1_RAT               Reviewed;         465 AA.
AC   Q68FQ8;
DT   25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Deleted in lung and esophageal cancer protein 1 homolog;
GN   Name=Dlec1 {ECO:0000312|EMBL:AAH79413.1};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Essential for spermatogenesis and male fertility (By
CC       similarity). May play an important role in sperm head and tail
CC       formation (By similarity). May act as a tumor suppressor by inhibiting
CC       cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q8BLA1,
CC       ECO:0000250|UniProtKB:Q9Y238}.
CC   -!- SUBUNIT: Interacts with alpha-and beta-tubulin (By similarity).
CC       Interacts with BBS2, BBS4, BBS5, MKKS, TCP1, CCT2, CCT3, CCT4, CCT5 and
CC       CCT7 (By similarity). {ECO:0000250|UniProtKB:Q9Y238}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9Y238}.
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DR   EMBL; BC079413; AAH79413.1; -; mRNA.
DR   AlphaFoldDB; Q68FQ8; -.
DR   SMR; Q68FQ8; -.
DR   STRING; 10116.ENSRNOP00000043711; -.
DR   PaxDb; Q68FQ8; -.
DR   PRIDE; Q68FQ8; -.
DR   UCSC; RGD:1561649; rat.
DR   RGD; 1561649; Dlec1.
DR   eggNOG; ENOG502QQQ5; Eukaryota.
DR   InParanoid; Q68FQ8; -.
DR   PRO; PR:Q68FQ8; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005929; C:cilium; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0043014; F:alpha-tubulin binding; ISO:RGD.
DR   GO; GO:0048487; F:beta-tubulin binding; ISO:RGD.
DR   GO; GO:0015631; F:tubulin binding; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0002357; P:defense response to tumor cell; ISO:RGD.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:InterPro.
DR   GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
DR   InterPro; IPR033304; DLEC1.
DR   PANTHER; PTHR46348; PTHR46348; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Differentiation; Reference proteome; Spermatogenesis;
KW   Tumor suppressor.
FT   CHAIN           1..465
FT                   /note="Deleted in lung and esophageal cancer protein 1
FT                   homolog"
FT                   /id="PRO_0000079931"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          322..350
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..38
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   465 AA;  52915 MW;  5120736A43B7484F CRC64;
     MEPESKKELQ SPASSFVMSS ETMWESTPRQ PESTSLSWSP RKSLRSLTVF TDYCQFGYPT
     RSLRAGFQEL PPLPEPQTLR LRPASLRTQD ISHLLARVFR NLYTAQVIGD DLSDSLIKAR
     GSEDARHEEF LDQLQQARAI YKKRLDDVAM LEKHITQARA RDIAETEHAT KQGRLHVVEA
     PVKLPPVKTV FRWCIDNELM QKHHLISTED YYNDPLPFCP APKRSPTPMY SKMTFSCEKR
     FTHKSDLERK AEEHCRKLVE FDDLEYTTDS LRSVSKTKGK TKVTIKKAST PANKKWMEHL
     QVPQRALDRR LLARMQNRNH YLKNPRFFPP NTPHGGKSLI VPSRKPERRG SLSAKPEWRC
     VCSSRRIPGN VSFRVNLDLV YGGPQTLASQ GSVPEESGVL GSTSGMAFDP QGPRVRLFSA
     VRSRGVDPWE PVWASSGHPK WGGAGAGAYS HVTLAWYVDY LFLLL