DLG2_DANRE
ID DLG2_DANRE Reviewed; 881 AA.
AC Q5PYH7;
DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Disks large homolog 2;
DE AltName: Full=Postsynaptic density protein 93;
DE Short=PSD-93;
GN Name=dlg2;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX PubMed=15660367; DOI=10.1002/neu.20118;
RA Meyer M.P., Trimmer J.S., Gilthorpe J.D., Smith S.J.;
RT "Characterization of zebrafish PSD-95 gene family members.";
RL J. Neurobiol. 63:91-105(2005).
CC -!- FUNCTION: May play a role in synapse assembly and function.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q91XM9};
CC Lipid-anchor {ECO:0000250|UniProtKB:Q63622}. Postsynaptic density
CC {ECO:0000250|UniProtKB:Q63622}. Synapse {ECO:0000250}. Membrane
CC {ECO:0000250|UniProtKB:Q63622}. Cell projection, axon
CC {ECO:0000250|UniProtKB:Q63622}. Perikaryon
CC {ECO:0000250|UniProtKB:Q63622}.
CC -!- DEVELOPMENTAL STAGE: At 4 days-post-fertilization (dpf), expressed
CC strongly in the inner and outer plexiform layers and ganglion cell
CC layer of the retina, in the tegmentum and in the hindbrain. Also
CC expressed diffusely in the diencephalon. {ECO:0000269|PubMed:15660367}.
CC -!- SIMILARITY: Belongs to the MAGUK family. {ECO:0000305}.
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DR EMBL; AY819033; AAV68498.1; -; mRNA.
DR RefSeq; NP_001012378.1; NM_001012378.3.
DR AlphaFoldDB; Q5PYH7; -.
DR SMR; Q5PYH7; -.
DR STRING; 7955.ENSDARP00000073282; -.
DR PaxDb; Q5PYH7; -.
DR ABCD; Q5PYH7; 1 sequenced antibody.
DR GeneID; 497638; -.
DR KEGG; dre:497638; -.
DR CTD; 1740; -.
DR ZFIN; ZDB-GENE-050221-3; dlg2.
DR eggNOG; KOG0708; Eukaryota.
DR InParanoid; Q5PYH7; -.
DR OrthoDB; 807583at2759; -.
DR PhylomeDB; Q5PYH7; -.
DR TreeFam; TF323171; -.
DR PRO; PR:Q5PYH7; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0016323; C:basolateral plasma membrane; IBA:GO_Central.
DR GO; GO:0030054; C:cell junction; IBA:GO_Central.
DR GO; GO:0031594; C:neuromuscular junction; IBA:GO_Central.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR GO; GO:0098839; C:postsynaptic density membrane; IBA:GO_Central.
DR GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0045197; P:establishment or maintenance of epithelial cell apical/basal polarity; IBA:GO_Central.
DR GO; GO:0043113; P:receptor clustering; IBA:GO_Central.
DR GO; GO:0097120; P:receptor localization to synapse; IBA:GO_Central.
DR GO; GO:0050808; P:synapse organization; NAS:UniProtKB.
DR CDD; cd12032; SH3_DLG2; 1.
DR Gene3D; 2.30.42.10; -; 3.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR016313; DLG1-like.
DR InterPro; IPR019590; DLG1_PEST_dom.
DR InterPro; IPR035759; DLG2_SH3.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR019583; PDZ_assoc.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF10608; MAGUK_N_PEST; 1.
DR Pfam; PF00595; PDZ; 3.
DR Pfam; PF10600; PDZ_assoc; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PIRSF; PIRSF001741; MAGUK_DLGH; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM01277; MAGUK_N_PEST; 1.
DR SMART; SM00228; PDZ; 3.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SSF50044; 1.
DR SUPFAM; SSF50156; SSF50156; 3.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 3.
DR PROSITE; PS50002; SH3; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Cell projection; Lipoprotein; Membrane; Reference proteome;
KW Repeat; SH3 domain; Synapse.
FT CHAIN 1..881
FT /note="Disks large homolog 2"
FT /id="PRO_0000094556"
FT DOMAIN 155..242
FT /note="PDZ 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT DOMAIN 250..337
FT /note="PDZ 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT DOMAIN 424..505
FT /note="PDZ 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT DOMAIN 539..609
FT /note="SH3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT DOMAIN 683..866
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00100"
FT REGION 16..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 63..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 709..729
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 881 AA; 98508 MW; 18C0D2973A2FBF90 CRC64;
MKAVVRVLKL EERAVHRQQN RPPAVQGSQH QSHSPACMNP ALMSSPWVRQ KHGGRAIPNR
LCLSTTDSPH SYRYQDDDSP PPEHSFPRLT NEVRAPELVH VSEKNLSEIE NVHGYVSHSH
ISPLKASPAP IIVNTDTLES VPYVNGTEIE YEFEEITLER GNSGLGFSIA GGTDNPHIGD
DPGIFITKII PGGAAAEDGR LRVNDCILRV NESDVSEVSH SKAVEALKAA GSIVRLYVRR
RRPMLETVTE IKLIKGPKGL GFSIAGGVGN QHIPGDNSIY VTKIIDGGAA QKDGRLQVGD
RLLMVNNYTL EEVTHEEAVA ILKNTSDVVY LKVGKPTSVY LSDPYGPPDI THSFSPAMEN
HISSPGNNGT LEYKSSLPPI SPGRYSPLPK HLLGEEDINR NPSLDEMEGH RFDSQHFQLR
EPRKIVLHKG STGLGFNIVG GEDGEGIFVS FILAGGPADL SGELRRGDQI LSVNGIDLRG
ATHEQAAAAL KGAGQTVTII AQYRPEEYGR FEAKIHDLRE QMMNHSMSSG SGSLRTNQKR
SLYVRALFDY ERAKDSGLPS QGLSFRYGDI LHVINASDDE WWQARRVTPE GDSEEMGVIP
SKRRVERKER ARLKTVKFNA KPGSLDSKGS FSEKRRKNFI FSRKFPFYKN KDADEQDGSD
SERSQEELIL SYEPVIRQEI NYARPVIILG PMKDRINDDL ISEFPDKFGS CVPPANSSDQ
EDTTRPKRDY EVDGRDYHFM ASREQMEKDI QEHKFIEAGQ YNDNLYGTSV QSVKYVAERG
KHCILDVSGN AIKRLQVAQL YPIAIFIKPR SIESLMEMNK RLTEEQAKKT YDRAMKLEQE
FGEYFTALVQ GDTLEDIYNQ CKMVIEEQSG PYIWIPSKEK L
