ID   DLGP1_DANRE             Reviewed;         999 AA.
AC   Q7ZYZ6;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 2.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Disks large-associated protein 1;
DE            Short=DAP-1;
DE   AltName: Full=Guanylate kinase-associated protein;
GN   Name=dlgap1 {ECO:0000312|ZFIN:ZDB-GENE-030616-580}; ORFNames=si:zc142h2.3;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
CC   -!- FUNCTION: Part of the postsynaptic scaffold in neuronal cells.
CC       {ECO:0000250|UniProtKB:P97836}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}. Postsynaptic density {ECO:0000250}. Synapse
CC       {ECO:0000250}. Note=Found in postsynaptic density of neuronal cells.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SAPAP family. {ECO:0000255}.
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DR   EMBL; AL845362; CAD60846.1; -; Genomic_DNA.
DR   RefSeq; NP_001189384.1; NM_001202455.1.
DR   AlphaFoldDB; Q7ZYZ6; -.
DR   SMR; Q7ZYZ6; -.
DR   STRING; 7955.ENSDARP00000113100; -.
DR   PaxDb; Q7ZYZ6; -.
DR   GeneID; 569898; -.
DR   KEGG; dre:569898; -.
DR   CTD; 569898; -.
DR   ZFIN; ZDB-GENE-030616-580; dlgap1a.
DR   eggNOG; KOG3971; Eukaryota.
DR   InParanoid; Q7ZYZ6; -.
DR   OrthoDB; 285447at2759; -.
DR   PhylomeDB; Q7ZYZ6; -.
DR   TreeFam; TF321382; -.
DR   Reactome; R-DRE-6794361; Neurexins and neuroligins.
DR   PRO; PR:Q7ZYZ6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0098978; C:glutamatergic synapse; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
DR   GO; GO:0099572; C:postsynaptic specialization; IBA:GO_Central.
DR   GO; GO:0060090; F:molecular adaptor activity; IBA:GO_Central.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR   GO; GO:0098962; P:regulation of postsynaptic neurotransmitter receptor activity; IBA:GO_Central.
DR   InterPro; IPR030524; DLGAP1.
DR   InterPro; IPR005026; SAPAP.
DR   PANTHER; PTHR12353; PTHR12353; 1.
DR   PANTHER; PTHR12353:SF7; PTHR12353:SF7; 1.
DR   Pfam; PF03359; GKAP; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Synapse.
FT   CHAIN           1..999
FT                   /note="Disks large-associated protein 1"
FT                   /id="PRO_0000248260"
FT   REGION          155..213
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          395..418
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          918..989
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           997..999
FT                   /note="PDZ-binding"
FT                   /evidence="ECO:0000250|UniProtKB:P97836"
FT   COMPBIAS        918..936
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        943..969
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   999 AA;  110828 MW;  9313832694BB6164 CRC64;
     MKGLSGSRSH HHVVTCDPSF ESMGHHLDHK PYLISQIDNP HPVDHSYYSQ RSPYQPDCVV
     PYGTFPRRHY SSQHELKDEM AVVPYSGGGV PASKGQQRLP VALLDQFDRQ LPVPRDGYHT
     LQYKRAAAAL EQRSDSPGRI RHLVHSVQKL FTKSHSLEGP HHGHGHGKGS INGGKASPDG
     EPPAIRHRKR SKSRERCKSA EPKNRTPPSG YWSSDELERE ACLFHHGPPG VMTMGRHPDK
     SQSQYFLEAY NTINDQALKN SRSNNDLGKC STCTSIPLSV DASQLVKKSS WSSSLTVSRA
     RQVYQKASVN VDKALVKAEA CQQERSCQFL QLWKCVFVEL SVCLDADMHV WAKVCDVASL
     LNRQVPQDEW GGFPLGKDED IPCRRMRSGS YVKAMAEDDS GDSDGSPKPS PKMQARRASY
     LKATQPSLTE MTTLKISQEH SPKLQIRSHS YLRAVSEVSI NRSLDTLDPK ALLASPQYRS
     RNESYMRAMS TISQIEAMCE SVFNEMESHA VDALDLPMPG CFRMRSHSYV RAIDQGCSQD
     DDSPLLPASP PRTTTTVRTI QSSTVSSCIT TYKKTPPPVP PRTSTKPFIS ITAQSSTESA
     QDAYMDGPGT RGEPVLHSGL SNSTESIDSM KALTAAIEAA NAQIHGPASQ HVSNSTMTIS
     TAPPSPLPLP VPVPVPIPIP ALEDVRRDVL RKSRCLSIGI QSKFQSVGVQ VEEEHGVTTA
     VQADLDTPDY TPADSPVTDF PAAGCLSRQY SRDAATSTVS IQGSGNHYHA CTSDDYEDVG
     FDPSILPPPD PWIDSVIEDS LEVVGRSVCQ RDGRWFLKLL QAETERMEGW CRQMEHDEKE
     NKMPDEVLGK IRGAVGSAQL LMSQKFQQFR ELCEENLNPN AHPRPVAQDL AGFWDMLQLS
     IENISLKFDE LHQLKANNWR PLDPPERKER RLPPPVPKKP PKAHPPLARD RSLESTEKQR
     QEARKRLMAA KRAASVRQNS ATESADSIEI YIPEAQTRL