ID   DLH1_CANAX              Reviewed;         324 AA.
AC   P50265;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Meiotic recombination protein DLH1;
DE   AltName: Full=DMC1 homolog;
GN   Name=DLH1;
OS   Candida albicans (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=5476;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8725225; DOI=10.1093/genetics/143.2.769;
RA   Diener A.C., Fink G.R.;
RT   "DLH1 is a functional Candida albicans homologue of the meiosis-specific
RT   gene DMC1.";
RL   Genetics 143:769-776(1996).
CC   -!- FUNCTION: Required for meiotic recombination, synaptonemal complex
CC       formation and cell cycle progression. {ECO:0000250}.
CC   -!- SUBUNIT: Double stacked ring-shaped homooctamer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the RecA family. DMC1 subfamily. {ECO:0000305}.
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DR   EMBL; U39808; AAC49400.1; -; Genomic_DNA.
DR   PIR; S70390; S70390.
DR   AlphaFoldDB; P50265; -.
DR   SMR; P50265; -.
DR   VEuPathDB; FungiDB:C1_12560C_A; -.
DR   VEuPathDB; FungiDB:CAWG_00186; -.
DR   GO; GO:0000794; C:condensed nuclear chromosome; IEA:EnsemblFungi.
DR   GO; GO:0005524; F:ATP binding; ISS:UniProtKB.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0042030; F:ATPase inhibitor activity; IEA:EnsemblFungi.
DR   GO; GO:0000150; F:DNA strand exchange activity; ISS:UniProtKB.
DR   GO; GO:0003690; F:double-stranded DNA binding; ISS:UniProtKB.
DR   GO; GO:0042802; F:identical protein binding; IEA:EnsemblFungi.
DR   GO; GO:0003697; F:single-stranded DNA binding; ISS:UniProtKB.
DR   GO; GO:1905334; F:Swi5-Sfr1 complex binding; IEA:EnsemblFungi.
DR   GO; GO:0000730; P:DNA recombinase assembly; IEA:EnsemblFungi.
DR   GO; GO:0006311; P:meiotic gene conversion; IEA:EnsemblFungi.
DR   GO; GO:0000709; P:meiotic joint molecule formation; IEA:EnsemblFungi.
DR   GO; GO:0010774; P:meiotic strand invasion involved in reciprocal meiotic recombination; IEA:EnsemblFungi.
DR   GO; GO:0051260; P:protein homooligomerization; IEA:EnsemblFungi.
DR   GO; GO:0007130; P:synaptonemal complex assembly; IEA:EnsemblFungi.
DR   CDD; cd01123; Rad51_DMC1_radA; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011940; Dmc1.
DR   InterPro; IPR013632; DNA_recomb/repair_Rad51_C.
DR   InterPro; IPR016467; DNA_recomb/repair_RecA-like.
DR   InterPro; IPR010995; DNA_repair_Rad51/TF_NusA_a-hlx.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR033925; Rad51_DMC1_RadA.
DR   InterPro; IPR020588; RecA_ATP-bd.
DR   InterPro; IPR020587; RecA_monomer-monomer_interface.
DR   Pfam; PF08423; Rad51; 1.
DR   PIRSF; PIRSF005856; Rad51; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF47794; SSF47794; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR02238; recomb_DMC1; 1.
DR   PROSITE; PS50162; RECA_2; 1.
DR   PROSITE; PS50163; RECA_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell cycle; DNA-binding; Meiosis; Nucleotide-binding; Nucleus.
FT   CHAIN           1..324
FT                   /note="Meiotic recombination protein DLH1"
FT                   /id="PRO_0000122917"
FT   BINDING         112..119
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   BINDING         214
FT                   /ligand="dsDNA"
FT                   /ligand_id="ChEBI:CHEBI:4705"
FT                   /evidence="ECO:0000250|UniProtKB:Q14565"
FT   BINDING         214
FT                   /ligand="ssDNA"
FT                   /ligand_id="ChEBI:CHEBI:9160"
FT                   /evidence="ECO:0000250|UniProtKB:Q14565"
FT   BINDING         217
FT                   /ligand="ssDNA"
FT                   /ligand_id="ChEBI:CHEBI:9160"
FT                   /evidence="ECO:0000250|UniProtKB:Q14565"
FT   BINDING         220
FT                   /ligand="dsDNA"
FT                   /ligand_id="ChEBI:CHEBI:4705"
FT                   /evidence="ECO:0000250|UniProtKB:Q14565"
FT   BINDING         220
FT                   /ligand="ssDNA"
FT                   /ligand_id="ChEBI:CHEBI:9160"
FT                   /evidence="ECO:0000250|UniProtKB:Q14565"
FT   BINDING         226
FT                   /ligand="dsDNA"
FT                   /ligand_id="ChEBI:CHEBI:4705"
FT                   /evidence="ECO:0000250|UniProtKB:Q14565"
FT   BINDING         226
FT                   /ligand="ssDNA"
FT                   /ligand_id="ChEBI:CHEBI:9160"
FT                   /evidence="ECO:0000250|UniProtKB:Q14565"
FT   BINDING         296
FT                   /ligand="ssDNA"
FT                   /ligand_id="ChEBI:CHEBI:9160"
FT                   /evidence="ECO:0000250|UniProtKB:Q14565"
SQ   SEQUENCE   324 AA;  35281 MW;  95CD769514D9CF82 CRC64;
     MSVEDSIISI DSLQDQGINA GDINKLKSAG ICSITSVLST TRRNLTKIKG LSEIKVEKIK
     EAAGKIKKYG FLPATIVAES RTKVFHITTG SKQFDEILGG GIQSMSITEV FGEFRCGKTQ
     LCHTLCVAAQ LPTDMGGGEG RVAYIDTEGT FRPDRIRSIA ERYGVDADIC LENISYARAL
     NSEHQIELVE QLGNELAEGT FRLLIVDSIM ACFRVDYSGR GELNERQQKL NQHLSNLTRV
     AEDYNIAVFL TNQVQSDPGA SALFAAADGR KPVGGHVLAH ASATRILLRK GRGEERVAKL
     QDSPNMPEKE CVYVIGEGGI KDTD