ID   DLL1_XENLA              Reviewed;         250 AA.
AC   P53773;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Homeobox protein DLL-1;
DE            Short=DLL;
DE            Short=XDLL;
GN   Name=dll1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1347527; DOI=10.1016/s0021-9258(18)42726-3;
RA   Asano M., Emori Y., Saigo K., Shiokawa K.;
RT   "Isolation and characterization of a Xenopus cDNA which encodes a
RT   homeodomain highly homologous to Drosophila Distal-less.";
RL   J. Biol. Chem. 267:5044-5047(1992).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the distal-less homeobox family. {ECO:0000305}.
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DR   EMBL; D10259; -; NOT_ANNOTATED_CDS; mRNA.
DR   PIR; A42103; A42103.
DR   AlphaFoldDB; P53773; -.
DR   SMR; P53773; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..250
FT                   /note="Homeobox protein DLL-1"
FT                   /id="PRO_0000049036"
FT   DNA_BIND        125..184
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          40..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          84..106
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   250 AA;  28038 MW;  F54981F02AB941A1 CRC64;
     MTTMADGLEA QDSSKSAFME FGQQQSHSQQ SSPVMAAGHY PSLHCLHSGS HHHPQHQHDT
     NYSGSNSYSR SLAAYPYMSH SQHSPYLQSC NSNTTTQSRA EEPDQQKTTV IENGEIRFNG
     KGKKIRKPRT IYSSLQLQAL NHRFQQTQYL ALPERAELAA SLGVTQTQVK IWFQNKRSKY
     KKLIKQGNNP LEIDQLAGTV ALSPRSPAIP PVWDVSASKG VSMAPNSYMP GYSHWYSSPH
     QDTMQRSQMM