ID   DLL2_XENLA              Reviewed;         277 AA.
AC   P53774; Q0IH82;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Homeobox protein DLL-2;
DE            Short=XDLL-2;
GN   Name=dll2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7915132; DOI=10.1016/0925-4773(94)90038-8;
RA   Dirksen M.L., Morasso M.I., Sargent T.D., Jamrich M.;
RT   "Differential expression of a Distal-less homeobox gene Xdll-2 in
RT   ectodermal cell lineages.";
RL   Mech. Dev. 46:63-70(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May have a regulatory function in the initial formation of
CC       the epidermis.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- TISSUE SPECIFICITY: Expressed in the embryonic ectoderm and is
CC       specifically repressed in the CNS. High level of expression in adult
CC       skin.
CC   -!- SIMILARITY: Belongs to the distal-less homeobox family. {ECO:0000305}.
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DR   EMBL; S74210; AAB31740.2; -; mRNA.
DR   EMBL; BC123268; AAI23269.1; -; mRNA.
DR   RefSeq; NP_001090515.1; NM_001097046.1.
DR   AlphaFoldDB; P53774; -.
DR   SMR; P53774; -.
DR   DNASU; 779428; -.
DR   GeneID; 779428; -.
DR   KEGG; xla:779428; -.
DR   CTD; 779428; -.
DR   Xenbase; XB-GENE-5879348; dlx3.L.
DR   OrthoDB; 1416398at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 779428; Expressed in zone of skin and 4 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR022135; Distal-less_N.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF12413; DLL_N; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..277
FT                   /note="Homeobox protein DLL-2"
FT                   /id="PRO_0000049037"
FT   DNA_BIND        130..189
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          191..277
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        12..33
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        197..265
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   277 AA;  31656 MW;  298F1BD60A53CB5A CRC64;
     MSGPYEKKMA VLTDLSTSSH PVTKDSPTLP ESSATDMGYY NGHLSTGQHD FFQTQAYSPT
     ISSYGYPHPP HPQYNFNGLV GNESFLPKDD YQYGYRPFVH YREPPVQETV SVKEEPETEV
     RMVNGKPKKI RKPRTIYSSY QLAALQRRFQ KAQYLALPER AELAAQLGLT QTQVKIWFQN
     RRSKFKKLYK NGEGPDMEHS PNNSDSMACN SPSSPPIWDN SGSRTPLQQQ QQQQSLPQCS
     SPSYLENYHS WYTQQNQSGQ HLQPSEVMHQ PPPDTVY