DLL3_RAT
ID DLL3_RAT Reviewed; 589 AA.
AC O88671;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Delta-like protein 3;
DE AltName: Full=Drosophila Delta homolog 3;
DE Short=Delta3;
DE Flags: Precursor;
GN Name=Dll3;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Boulter J., Greenfield A., Weinmaster G.;
RT "Rattus norvegicus mRNA for Delta 3: a putative ligand for Notch.";
RL Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Inhibits primary neurogenesis. May be required to divert
CC neurons along a specific differentiation pathway. Plays a role in the
CC formation of somite boundaries during segmentation of the paraxial
CC mesoderm (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Can bind and activate Notch-1 or another Notch receptor.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
CC -!- DOMAIN: The DSL domain is required for binding to the Notch receptor.
CC -!- PTM: Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis
CC and subsequent degradation. {ECO:0000250}.
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DR EMBL; AF084576; AAC33303.1; -; mRNA.
DR RefSeq; NP_446118.1; NM_053666.1.
DR AlphaFoldDB; O88671; -.
DR SMR; O88671; -.
DR STRING; 10116.ENSRNOP00000026182; -.
DR PaxDb; O88671; -.
DR PRIDE; O88671; -.
DR ABCD; O88671; 8 sequenced antibodies.
DR GeneID; 114125; -.
DR KEGG; rno:114125; -.
DR UCSC; RGD:70953; rat.
DR CTD; 10683; -.
DR RGD; 70953; Dll3.
DR eggNOG; KOG1217; Eukaryota.
DR InParanoid; O88671; -.
DR OrthoDB; 394787at2759; -.
DR PhylomeDB; O88671; -.
DR PRO; PR:O88671; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005112; F:Notch binding; IPI:RGD.
DR GO; GO:0001709; P:cell fate determination; TAS:RGD.
DR GO; GO:0007417; P:central nervous system development; IEP:RGD.
DR GO; GO:0007386; P:compartment pattern specification; ISO:RGD.
DR GO; GO:0048712; P:negative regulation of astrocyte differentiation; IDA:RGD.
DR GO; GO:0050768; P:negative regulation of neurogenesis; ISO:RGD.
DR GO; GO:0045746; P:negative regulation of Notch signaling pathway; IDA:RGD.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0048339; P:paraxial mesoderm development; ISO:RGD.
DR GO; GO:0050769; P:positive regulation of neurogenesis; IDA:RGD.
DR GO; GO:0001501; P:skeletal system development; ISS:UniProtKB.
DR GO; GO:0001756; P:somitogenesis; ISO:RGD.
DR GO; GO:0009888; P:tissue development; ISO:RGD.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR Pfam; PF00008; EGF; 2.
DR Pfam; PF12661; hEGF; 3.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00179; EGF_CA; 5.
DR PROSITE; PS00022; EGF_1; 6.
DR PROSITE; PS01186; EGF_2; 5.
DR PROSITE; PS50026; EGF_3; 6.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; Disulfide bond; EGF-like domain;
KW Membrane; Notch signaling pathway; Reference proteome; Repeat; Signal;
KW Transmembrane; Transmembrane helix; Ubl conjugation.
FT SIGNAL 1..32
FT /evidence="ECO:0000250"
FT CHAIN 33..589
FT /note="Delta-like protein 3"
FT /id="PRO_0000007511"
FT TOPO_DOM 33..494
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 495..515
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 516..589
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 174..213
FT /note="DSL"
FT DOMAIN 218..251
FT /note="EGF-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 276..312
FT /note="EGF-like 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 314..353
FT /note="EGF-like 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 355..391
FT /note="EGF-like 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 393..429
FT /note="EGF-like 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 431..467
FT /note="EGF-like 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT REGION 552..574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 222..233
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 226..239
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 241..250
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 280..291
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 285..300
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 302..311
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 318..329
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 323..341
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 343..352
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 359..370
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 364..379
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 381..390
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 397..408
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 402..417
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 419..428
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 435..446
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 440..455
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 457..466
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 589 AA; 61425 MW; A17B3BF9B95EC17F CRC64;
MVSLQVSSLP QTLILAFLLP QALPAGVFEL QIHSFGPGPG PGTPRSPCNA RGPCRLFFRV
CLKPGVSQEA AESLCALGAA LSTSGPVYTE QPGVPAAALS LPDGLVRVPF LDAWPGTFSL
IIETWREQLG ERAAGPAWNL LARVAGRRRL AAGAPWARDV QRTGAWELHF SYRARCEPPA
VGAACARLCR SRSAPSRCGP GLRPCTPFPD ECEAPRESLT VCRAGCSPEH GYCEEPDECH
CLEGWTGPLC TVPVSTSSCL NSRVSGPAGT GCLLPGPGPC DGNPCANGGS CSETPGSFEC
ACPRGFYGPR CEVSGVTCAD GPCFNGGLCV GGEDPDSAYV CHCPPAFQGS NCERRVDRCS
LQPCQNGGLC LDLGHALRCR CRAGFAGPRC EHDLDDCAGR ACANGGTCVE GGGARRCSCA
LGFGGRDCRE RADPCASRPC AHGGRCYAHF SGLVCACAPG YMGVRCEFAV RPDGADAVPA
APRGLRQADS QRFLLPPALG LLAAAALAGA ALLLIHVRRR GPGRDTGTRL LSGTREPSVH
TLPDALNNLR LQDGAGDGPT SSADWNHPED GDSRSIYVIP APSIYAREA
