ID   DLL3_XENLA              Reviewed;         289 AA.
AC   P54655; Q91729;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Homeobox protein DLL-3;
DE            Short=XDLL-3;
GN   Name=dll3;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Neurula;
RX   PubMed=8100768; DOI=10.1242/dev.117.3.961;
RA   Papalopulu N., Kintner C.R.;
RT   "Xenopus Distal-less related homeobox genes are expressed in the developing
RT   forebrain and are induced by planar signals.";
RL   Development 117:961-975(1993).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- TISSUE SPECIFICITY: Expression restricted to anterior ectodermal
CC       derivatives, namely the ventral forebrain, the cranial neural crest and
CC       the cement gland. Also expressed in the olfactory and otic placodes.
CC   -!- SIMILARITY: Belongs to the distal-less homeobox family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA02622.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; L09729; AAA02623.1; -; mRNA.
DR   EMBL; L09729; AAA02622.1; ALT_INIT; mRNA.
DR   PIR; I51410; I51410.
DR   AlphaFoldDB; P54655; -.
DR   BMRB; P54655; -.
DR   SMR; P54655; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR022135; Distal-less_N.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF12413; DLL_N; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..289
FT                   /note="Homeobox protein DLL-3"
FT                   /id="PRO_0000049038"
FT   DNA_BIND        137..196
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          16..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          198..254
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        18..41
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        203..254
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   289 AA;  31932 MW;  541D92AD6DA20091 CRC64;
     MTGVYERRVA SIRASEFQSM MHHPSQDSPT LPESTATDSG YYSPGAAAGH PHHGYCSPTS
     ATYGKALNAY QYQYHGMNGA AANYSGKAYS DYGYGSPYHP HHQYSGAYNR VQPPSTQPEK
     EVSEPEVRMV NGKPKKIRKP RTIYSSFQLA ALQRRFQKTQ YLALPERAEL AASLGLTQTQ
     VKIWFQNKRS KIKKIMKNGE LPPEHSPSSS DPMACNSPQS PVVWEPQGSS RSLSHHPHVH
     SHPQPSSSSP ASSYLENSGV WYPTGTHLQN LQNHASLQHP LALASGTLY