ID   DLL4_XENLA              Reviewed;         285 AA.
AC   P53775;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Homeobox protein DLL-4;
DE            Short=XDLL-4;
GN   Name=dll4;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Neurula;
RX   PubMed=8100768; DOI=10.1242/dev.117.3.961;
RA   Papalopulu N., Kintner C.R.;
RT   "Xenopus Distal-less related homeobox genes are expressed in the developing
RT   forebrain and are induced by planar signals.";
RL   Development 117:961-975(1993).
CC   -!- FUNCTION: Involved in the Notch signaling pathway as Notch ligand.
CC       Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively
CC       regulates endothelial cell proliferation and migration and angiogenic
CC       sprouting. Essential for retinal progenitor proliferation is required
CC       for suppressing rod fates in late retinal progenitors as well as for
CC       proper generation of other retinal cell types. During spinal cord
CC       neurogenesis, inhibits V2a interneuron fate (By similarity).
CC       {ECO:0000250|UniProtKB:Q9JI71, ECO:0000250|UniProtKB:Q9NR61}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- TISSUE SPECIFICITY: Expression restricted to anterior ectodermal
CC       derivatives, namely the ventral forebrain, the cranial neural crest and
CC       the cement gland. Also expressed in the developing eye.
CC   -!- SIMILARITY: Belongs to the distal-less homeobox family. {ECO:0000305}.
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DR   EMBL; L09728; AAA02621.1; -; mRNA.
DR   PIR; I51412; I51412.
DR   RefSeq; NP_001084032.1; NM_001090563.2.
DR   AlphaFoldDB; P53775; -.
DR   SMR; P53775; -.
DR   GeneID; 399264; -.
DR   KEGG; xla:399264; -.
DR   CTD; 399264; -.
DR   Xenbase; XB-GENE-852896; dlx2.L.
DR   OMA; WYHQASS; -.
DR   OrthoDB; 1416398at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 399264; Expressed in brain and 8 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0060579; P:ventral spinal cord interneuron fate commitment; ISS:UniProtKB.
DR   GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR022135; Distal-less_N.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF12413; DLL_N; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Angiogenesis; Developmental protein; Differentiation; DNA-binding;
KW   Homeobox; Neurogenesis; Nucleus; Reference proteome; Sensory transduction;
KW   Vision.
FT   CHAIN           1..285
FT                   /note="Homeobox protein DLL-4"
FT                   /id="PRO_0000049039"
FT   DNA_BIND        127..186
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          17..47
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          96..115
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          188..238
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        195..238
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   285 AA;  31361 MW;  507A537E5D8D59EB CRC64;
     MTGVFDSLAA DMHSNHMPSS SYHSLHKSQE SPTLPVSTAT DSSYYTNQQQ QQHCGAVSPY
     GQLGSYQFHG AAINGISYST KSYDLSYTGS YSSYGPYGTS PSPPHNDQEK EDCEPEVRMV
     NGKPKKVRKP RTIYSSFQLA ALQRRFQKTQ YLALPERAEL AASLGVTQTQ VKIWFQNRRS
     KFKKMWKSGE IPSDQLPVGS ESSPCSSPSA STATWDFGPH QRLQGATNGS ALQSSNSASS
     PSPFLSNYSW YQTSNSAPHL QSNPLLQQHH LHHHPPAPIS AGTIF