ID   DLLH_BRAFL              Reviewed;         321 AA.
AC   P53772;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Homeobox protein DLL homolog;
OS   Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC   Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC   Branchiostomidae; Branchiostoma.
OX   NCBI_TaxID=7739;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8787764; DOI=10.1242/dev.122.9.2911;
RA   Holland N.D., Panganiban G.E., Henyey E.L., Holland L.Z.;
RT   "Sequence and developmental expression of AmphiDll, an amphioxus Distal-
RT   less gene transcribed in the ectoderm, epidermis and nervous system:
RT   insights into evolution of craniate forebrain and neural crest.";
RL   Development 122:2911-2920(1996).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the distal-less homeobox family. {ECO:0000305}.
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DR   EMBL; U47058; AAB36860.1; -; mRNA.
DR   AlphaFoldDB; P53772; -.
DR   SMR; P53772; -.
DR   STRING; 7739.XP_002612943.1; -.
DR   eggNOG; KOG0850; Eukaryota.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus.
FT   CHAIN           1..321
FT                   /note="Homeobox protein DLL homolog"
FT                   /id="PRO_0000049045"
FT   DNA_BIND        116..175
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          79..118
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          173..244
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        83..112
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        190..241
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   321 AA;  35437 MW;  F4408D46FE1443C7 CRC64;
     MEIPPVQQTP VSMSMNHSSY PVRCLHPTSH TQHESAFSTA APHSRPLGYP FSMNPMANHP
     GHPYGNPYST AAVTPVSESR LGGFSDDDNE RLYHFSRTDK SPDPTDQRIN GKGKKMRKPR
     TIYTSFQLQQ LNRRFQRTQY LALPERAELA AQLGLTQTQV KIWFQNRRSK YKKLMKQGGA
     PPPAVGTPNS SAPNPVQQQS GQPGHASPPG APTDLSDQQM SHGGQPNLPP RAPSQGQPQN
     GDDDAAWAAA TCHDQRRTNA DLLPTRMGRQ QYQSHGELHE LSPLLPLSMA LPGTAAAIPT
     TPNIERQQQY VLPPVNFLQR L