DLL_DROME
ID DLL_DROME Reviewed; 327 AA.
AC P20009; Q7KVF4; Q8MZ41; Q9W0Z8; Q9W0Z9;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 3.
DT 03-AUG-2022, entry version 195.
DE RecName: Full=Homeotic protein distal-less;
DE AltName: Full=Protein brista;
GN Name=Dll; Synonyms=Ba, BR; ORFNames=CG3629;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), FUNCTION, SUBCELLULAR LOCATION, AND
RP TISSUE SPECIFICITY.
RX PubMed=1358457; DOI=10.1016/0092-8674(92)90513-c;
RA Vachon G., Cohen B., Pfeifle C., McGuffin M.E., Botas J., Cohen S.M.;
RT "Homeotic genes of the Bithorax complex repress limb development in the
RT abdomen of the Drosophila embryo through the target gene Distal-less.";
RL Cell 71:437-450(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 124-184, AND FUNCTION.
RX PubMed=2564639; DOI=10.1038/338432a0;
RA Cohen S.M., Broenner G., Kuettner F., Juergens G., Jaeckle H.;
RT "Distal-less encodes a homoeodomain protein required for limb development
RT in Drosophila.";
RL Nature 338:432-434(1989).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 195-327 (ISOFORM B).
RC STRAIN=Berkeley; TISSUE=Larva, and Pupae;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [6]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=9303541; DOI=10.1101/gad.11.17.2259;
RA Gorfinkiel N., Morata G., Guerrero I.;
RT "The homeobox gene Distal-less induces ventral appendage development in
RT Drosophila.";
RL Genes Dev. 11:2259-2271(1997).
RN [7]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=9778507; DOI=10.1242/dev.125.22.4483;
RA Campbell G., Tomlinson A.;
RT "The roles of the homeobox genes aristaless and Distal-less in patterning
RT the legs and wings of Drosophila.";
RL Development 125:4483-4493(1998).
CC -!- FUNCTION: Transcription factor that plays a role in larval and adult
CC appendage development. Specifies the identity of ventral appendages
CC (including legs and antennae) and suppresses dorsal appendage
CC development. Involved in patterning the distal-proximal limb axis. May
CC control the adhesive properties of cells during limb morphogenesis.
CC Also has a secondary role in the normal patterning of the wing margin.
CC {ECO:0000269|PubMed:1358457, ECO:0000269|PubMed:2564639,
CC ECO:0000269|PubMed:9303541, ECO:0000269|PubMed:9778507}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC ECO:0000269|PubMed:1358457}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=A;
CC IsoId=P20009-1; Sequence=Displayed;
CC Name=B;
CC IsoId=P20009-2; Sequence=VSP_013806;
CC -!- TISSUE SPECIFICITY: Expressed in the embryo in limb primordia of the
CC head and thoracic segments. Expressed in regions of the larval leg,
CC wing, antennal and haltere disks that form the distal-most regions of
CC the mature structures (in the leg this corresponds to the tarsus and
CC the distal tibia). Found in the optic center of the developing larval
CC brain. {ECO:0000269|PubMed:1358457, ECO:0000269|PubMed:9303541,
CC ECO:0000269|PubMed:9778507}.
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DR EMBL; S47947; AAB24059.1; -; mRNA.
DR EMBL; AE013599; AAF47279.1; -; Genomic_DNA.
DR EMBL; AE013599; AAF47280.1; -; Genomic_DNA.
DR EMBL; AY113370; AAM29375.1; -; mRNA.
DR PIR; A44168; A44168.
DR RefSeq; NP_523857.1; NM_079133.2. [P20009-1]
DR RefSeq; NP_726486.1; NM_166689.2. [P20009-2]
DR AlphaFoldDB; P20009; -.
DR SMR; P20009; -.
DR BioGRID; 63542; 55.
DR IntAct; P20009; 37.
DR STRING; 7227.FBpp0289353; -.
DR DNASU; 37973; -.
DR EnsemblMetazoa; FBtr0072378; FBpp0072285; FBgn0000157. [P20009-2]
DR EnsemblMetazoa; FBtr0072379; FBpp0072286; FBgn0000157. [P20009-1]
DR GeneID; 37973; -.
DR KEGG; dme:Dmel_CG3629; -.
DR CTD; 37973; -.
DR FlyBase; FBgn0000157; Dll.
DR VEuPathDB; VectorBase:FBgn0000157; -.
DR eggNOG; KOG0850; Eukaryota.
DR GeneTree; ENSGT00940000167651; -.
DR HOGENOM; CLU_845370_0_0_1; -.
DR InParanoid; P20009; -.
DR OMA; YQHFAPQ; -.
DR PhylomeDB; P20009; -.
DR SignaLink; P20009; -.
DR BioGRID-ORCS; 37973; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 37973; -.
DR PRO; PR:P20009; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0000157; Expressed in ventral imaginal precursor (Drosophila) and 38 other tissues.
DR ExpressionAtlas; P20009; baseline and differential.
DR Genevisible; P20009; DM.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007487; P:analia development; TAS:FlyBase.
DR GO; GO:0007469; P:antennal development; IMP:UniProtKB.
DR GO; GO:0048264; P:determination of ventral identity; IMP:UniProtKB.
DR GO; GO:0035215; P:genital disc development; TAS:FlyBase.
DR GO; GO:0035114; P:imaginal disc-derived appendage morphogenesis; IMP:UniProtKB.
DR GO; GO:0007480; P:imaginal disc-derived leg morphogenesis; IMP:UniProtKB.
DR GO; GO:0007485; P:imaginal disc-derived male genitalia development; NAS:FlyBase.
DR GO; GO:0008587; P:imaginal disc-derived wing margin morphogenesis; IMP:UniProtKB.
DR GO; GO:0007479; P:leg disc proximal/distal pattern formation; IMP:FlyBase.
DR GO; GO:0016319; P:mushroom body development; IMP:FlyBase.
DR GO; GO:0010629; P:negative regulation of gene expression; IEP:FlyBase.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:FlyBase.
DR GO; GO:0048728; P:proboscis development; IMP:FlyBase.
DR GO; GO:0007449; P:proximal/distal pattern formation, imaginal disc; TAS:FlyBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0010092; P:specification of animal organ identity; IMP:UniProtKB.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR000047; HTH_motif.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Developmental protein; DNA-binding; Homeobox;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..327
FT /note="Homeotic protein distal-less"
FT /id="PRO_0000049055"
FT DNA_BIND 124..183
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 181..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..231
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..288
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 323..327
FT /note="Missing (in isoform B)"
FT /evidence="ECO:0000303|PubMed:12537569"
FT /id="VSP_013806"
FT CONFLICT 313
FT /note="Q -> L (in Ref. 1; AAB24059)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 327 AA; 35262 MW; E55137F35549E2F9 CRC64;
MDAPDAPHTP KYMDGGNTAA SVTPGINIPG KSAFVELQQH AAAGYGGIRS TYQHFGPQGG
QDSGFPSPRS ALGYPFPPMH QNSYSGYHLG SYAPPCASPP KDDFSISDKC EDSGLRVNGK
GKKMRKPRTI YSSLQLQQLN RRFQRTQYLA LPERAELAAS LGLTQTQVKI WFQNRRSKYK
KMMKAAQGPG TNSGMPLGGG GPNPGQHSPN QMHSGGNNGG GSNSGSPSHY LPPGHSPTPS
STPVSELSPE FPPTGLSPPT QAPWDQKPHW IDHKPPPQMT PQPPHPAATL HPQTHHHNPP
PQMGGYVPQY WYQPETNPSL VTVWPAV
