ID   DLPA_LEGPH              Reviewed;         615 AA.
AC   Q48806; Q5ZS36;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=Protein DlpA;
GN   Name=dlpA; OrderedLocusNames=lpg2683;
OS   Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC
OS   33152 / DSM 7513).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales;
OC   Legionellaceae; Legionella.
OX   NCBI_TaxID=272624;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7891566; DOI=10.1111/j.1365-2958.1994.tb01317.x;
RA   Berger K.H., Merriam J.J., Isberg R.R.;
RT   "Altered intracellular targeting properties associated with mutations in
RT   the Legionella pneumophila dotA gene.";
RL   Mol. Microbiol. 14:809-822(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Philadelphia 1 / ATCC 33152 / DSM 7513;
RX   PubMed=15448271; DOI=10.1126/science.1099776;
RA   Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M., Asamani G.,
RA   Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J., Steshenko V.,
RA   Park S.H., Zhao B., Teplitskaya E., Edwards J.R., Pampou S., Georghiou A.,
RA   Chou I.-C., Iannuccilli W., Ulz M.E., Kim D.H., Geringer-Sameth A.,
RA   Goldsberry C., Morozov P., Fischer S.G., Segal G., Qu X., Rzhetsky A.,
RA   Zhang P., Cayanis E., De Jong P.J., Ju J., Kalachikov S., Shuman H.A.,
RA   Russo J.J.;
RT   "The genomic sequence of the accidental pathogen Legionella pneumophila.";
RL   Science 305:1966-1968(2004).
CC   -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC       dehydrogenases family. {ECO:0000305}.
CC   -!- SIMILARITY: To M.jannaschii MJ0644 in the C-terminal section.
CC       {ECO:0000305}.
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DR   EMBL; U07940; AAA79904.1; -; Genomic_DNA.
DR   EMBL; AE017354; AAU28741.1; -; Genomic_DNA.
DR   PIR; S61390; S61390.
DR   RefSeq; WP_010948383.1; NC_002942.5.
DR   RefSeq; YP_096688.1; NC_002942.5.
DR   AlphaFoldDB; Q48806; -.
DR   SMR; Q48806; -.
DR   STRING; 272624.lpg2683; -.
DR   PaxDb; Q48806; -.
DR   PRIDE; Q48806; -.
DR   EnsemblBacteria; AAU28741; AAU28741; lpg2683.
DR   GeneID; 66491857; -.
DR   KEGG; lpn:lpg2683; -.
DR   PATRIC; fig|272624.6.peg.2864; -.
DR   eggNOG; COG0473; Bacteria.
DR   eggNOG; COG0684; Bacteria.
DR   HOGENOM; CLU_444666_0_0_6; -.
DR   OMA; CIIRENS; -.
DR   Proteomes; UP000000609; Chromosome.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   CDD; cd16841; RraA_family; 1.
DR   InterPro; IPR019818; IsoCit/isopropylmalate_DH_CS.
DR   InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR   InterPro; IPR005493; RraA/RraA-like.
DR   InterPro; IPR036704; RraA/RraA-like_sf.
DR   Pfam; PF00180; Iso_dh; 1.
DR   Pfam; PF03737; RraA-like; 1.
DR   SMART; SM01329; Iso_dh; 1.
DR   SUPFAM; SSF89562; SSF89562; 1.
DR   PROSITE; PS00470; IDH_IMDH; 1.
PE   3: Inferred from homology;
KW   NADP; Oxidoreductase; Reference proteome.
FT   CHAIN           1..615
FT                   /note="Protein DlpA"
FT                   /id="PRO_0000083821"
SQ   SEQUENCE   615 AA;  67705 MW;  78387A390E7695E4 CRC64;
     MKSTDPIKIA VLPGDGIGIE VTEATLPVFE VLDVPVILNY GDIGWEFWKK EGAAIPSRTW
     QLIASSDTVL LGAITSKPQR EAKQELSNAL KKSNPYYVSP VIQLRQGLDL FANVRPCFSI
     DDQSKPFNFC IIRENSEGLY CGFDYFPLPK AIHSLLAESQ HWQTIPADEA SCALRLQSKS
     GLTRLFDFAF KHAMQTGMPR VTLADKPNVL RESGEFTRKI FESTAQRYPK IQADILNVDA
     VALWLIKSPE KFGVIVAENM FGDILSDVGA GVMGGLGLAP SANIGDKGSY FEPVHGSGPR
     IRKNCANPSA MFLTISMLLN HFGYPDRAKK IVNAVMQVIK EKRFITYDLG GHATTTDMAN
     AVIEHCARLN ASCLSKDFNP TPKENLIESD TMPNLLQQLI NCNSAEISDA LDACGIEGGL
     LSIKPLSQGM KIIGPAYTIQ YLPREKKGTA FHNAANYIDK VPKHSVIVID NNGQIDCTVW
     GDLLTHTALR NNIMGTVVHG AVRDVESIRS TNYPVFCTGI YMCSGKNRVY KANEQCPLSI
     NGVTINPGDI IFADDNGVLV IPNDRLQEVV NKTIAIRLTE ERIKTAIASG STLEQAREDY
     CYEQPWLGIN KKRES