ID   DLPA_ORNAN              Reviewed;          66 AA.
AC   P0C8B2;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 1.
DT   25-MAY-2022, entry version 26.
DE   RecName: Full=Ornithorhynchus venom defensin-like peptide A {ECO:0000303|PubMed:18662710};
DE            Short=OvDLP-A {ECO:0000303|PubMed:18662710};
DE   Flags: Precursor;
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=18662710; DOI=10.1016/j.toxicon.2008.07.002;
RA   Whittington C.M., Papenfuss A.T., Kuchel P.W., Belov K.;
RT   "Expression patterns of platypus defensin and related venom genes across a
RT   range of tissue types reveal the possibility of broader functions for
RT   OvDLPs than previously suspected.";
RL   Toxicon 52:559-565(2008).
CC   -!- FUNCTION: Does not show antimicrobial, myotoxic, hemolytic and cell-
CC       promoting activities. {ECO:0000250|UniProtKB:P82140}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P82140}.
CC   -!- TISSUE SPECIFICITY: Produced by the crural gland and detected in venom
CC       from the spur located on each male hind leg. Is the only OvDLP that is
CC       expressed in venom gland alone. {ECO:0000269|PubMed:18662710}.
CC   -!- WEB RESOURCE: Name=Platypus resources;
CC       URL="https://www.twinkl.ch/search?q=platypus";
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DR   AlphaFoldDB; P0C8B2; -.
DR   SMR; P0C8B2; -.
DR   Proteomes; UP000002279; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.20.20.10; -; 1.
DR   InterPro; IPR012553; Defensin_3.
DR   InterPro; IPR023355; Myo_ane_neurotoxin_sf.
DR   Pfam; PF08131; Defensin_3; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Reference proteome; Secreted; Signal; Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..24
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000352731"
FT   CHAIN           25..66
FT                   /note="Ornithorhynchus venom defensin-like peptide A"
FT                   /id="PRO_0000352732"
FT   DISULFID        33..63
FT                   /evidence="ECO:0000250|UniProtKB:P82140"
FT   DISULFID        40..56
FT                   /evidence="ECO:0000250|UniProtKB:P82140"
FT   DISULFID        48..64
FT                   /evidence="ECO:0000250|UniProtKB:P82140"
SQ   SEQUENCE   66 AA;  7643 MW;  BE24177992E5A969 CRC64;
     MRLTYLLLLL VAVLFQAGSG SAEPIFFYGR QPCSYYDGVC RDKSDVNCKY IAFTYCENPN
     QRCCYY