DLRB1_RAT
ID DLRB1_RAT Reviewed; 96 AA.
AC P62628; O88567; Q9D812;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Dynein light chain roadblock-type 1;
DE AltName: Full=Bithoraxoid-like protein;
DE Short=BLP;
DE Short=robl/LC7-like protein;
DE AltName: Full=Dynein light chain 2A, cytoplasmic;
DE AltName: Full=Dynein-associated protein Km23;
GN Name=Dynlrb1; Synonyms=Dncl2a, Dnlc2a;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Visual cortex;
RX PubMed=10816553; DOI=10.1074/jbc.m000356200;
RA Ye F.C., Zangenenhpour S., Chaudhuri A.;
RT "Light-induced down-regulation of the rat class 1 dynein-associated protein
RT robl/LC7-like gene in visual cortex.";
RL J. Biol. Chem. 275:27172-27176(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Intestine;
RA Tang Q., Staub C.M., Mulder K.M.;
RT "Km23: role in growth factor signaling.";
RL Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pituitary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PROTEIN SEQUENCE OF 59-70, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=Sprague-Dawley; TISSUE=Hippocampus;
RA Lubec G., Diao W.;
RL Submitted (APR-2007) to UniProtKB.
RN [5]
RP ACETYLATION AT ALA-2, AND IDENTIFICATION BY MASS SPECTROMETRY.
RA Lubec G., Chen W.-Q.;
RL Submitted (FEB-2007) to UniProtKB.
CC -!- FUNCTION: Acts as one of several non-catalytic accessory components of
CC the cytoplasmic dynein 1 complex that are thought to be involved in
CC linking dynein to cargos and to adapter proteins that regulate dynein
CC function. Cytoplasmic dynein 1 acts as a motor for the intracellular
CC retrograde motility of vesicles and organelles along microtubules (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. The cytoplasmic dynein 1 complex consists of two
CC catalytic heavy chains (HCs) and a number of non-catalytic subunits
CC presented by intermediate chains (ICs), light intermediate chains
CC (LICs) and light chains (LCs); the composition seems to vary in respect
CC to the IC, LIC and LC composition. The heavy chain homodimer serves as
CC a scaffold for the probable homodimeric assembly of the respective non-
CC catalytic subunits. The ICs and LICs bind directly to the HC dimer and
CC the LCs assemble on the IC dimer. Interacts with DYNC1I1 and DYNC1I2.
CC Self-associates. Interacts with DYNLRB2. Interacts with RAB6A; the
CC interaction is direct. Interacts with RAB6B (GDP-bound) (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC -!- SIMILARITY: Belongs to the GAMAD family. {ECO:0000305}.
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DR EMBL; AF073839; AAC25580.2; -; mRNA.
DR EMBL; AY026512; AAK18711.1; -; mRNA.
DR EMBL; BC058437; AAH58437.1; -; mRNA.
DR RefSeq; NP_571985.1; NM_131910.3.
DR AlphaFoldDB; P62628; -.
DR BMRB; P62628; -.
DR SMR; P62628; -.
DR BioGRID; 250982; 1.
DR CORUM; P62628; -.
DR IntAct; P62628; 1.
DR MINT; P62628; -.
DR STRING; 10116.ENSRNOP00000060800; -.
DR iPTMnet; P62628; -.
DR PhosphoSitePlus; P62628; -.
DR jPOST; P62628; -.
DR PaxDb; P62628; -.
DR PRIDE; P62628; -.
DR GeneID; 170714; -.
DR KEGG; rno:170714; -.
DR UCSC; RGD:619910; rat.
DR CTD; 83658; -.
DR RGD; 619910; Dynlrb1.
DR VEuPathDB; HostDB:ENSRNOG00000025715; -.
DR eggNOG; KOG4115; Eukaryota.
DR HOGENOM; CLU_113002_3_2_1; -.
DR InParanoid; P62628; -.
DR OMA; CAMATLL; -.
DR OrthoDB; 1512428at2759; -.
DR PhylomeDB; P62628; -.
DR Reactome; R-RNO-5620924; Intraflagellar transport.
DR PRO; PR:P62628; -.
DR Proteomes; UP000002494; Chromosome 3.
DR Bgee; ENSRNOG00000025715; Expressed in cerebellum and 20 other tissues.
DR Genevisible; P62628; RN.
DR GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR GO; GO:0005813; C:centrosome; ISO:RGD.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005868; C:cytoplasmic dynein complex; ISS:UniProtKB.
DR GO; GO:0030286; C:dynein complex; ISO:RGD.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR GO; GO:0009416; P:response to light stimulus; IEP:RGD.
DR GO; GO:0008090; P:retrograde axonal transport; NAS:UniProtKB.
DR GO; GO:0007632; P:visual behavior; IDA:UniProtKB.
DR InterPro; IPR016561; DYNLRB1/2.
DR InterPro; IPR004942; Roadblock/LAMTOR2_dom.
DR Pfam; PF03259; Robl_LC7; 1.
DR PIRSF; PIRSF009998; DLC7; 1.
DR SMART; SM00960; Robl_LC7; 1.
PE 1: Evidence at protein level;
KW Acetylation; Cytoplasm; Cytoskeleton; Direct protein sequencing; Dynein;
KW Microtubule; Motor protein; Reference proteome; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|Ref.5"
FT CHAIN 2..96
FT /note="Dynein light chain roadblock-type 1"
FT /id="PRO_0000220957"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000269|Ref.5"
SQ SEQUENCE 96 AA; 10990 MW; 666734B413AFE7D0 CRC64;
MAEVEETLKR LQSQKGVQGI IVVNTEGIPI KSTMDNPTTT QYANLMHNFI LKARSTVREI
DPQNDLTFLR IRSKKNEIMV APDKDYFLIV IQNPTE
