ID   DLRB2_BOVIN             Reviewed;          96 AA.
AC   Q32P85;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Dynein light chain roadblock-type 2;
DE   AltName: Full=Dynein light chain 2B, cytoplasmic;
GN   Name=DYNLRB2; Synonyms=DNLC2B;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as one of several non-catalytic accessory components of
CC       the cytoplasmic dynein 1 complex that are thought to be involved in
CC       linking dynein to cargos and to adapter proteins that regulate dynein
CC       function. Cytoplasmic dynein 1 acts as a motor for the intracellular
CC       retrograde motility of vesicles and organelles along microtubules (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer (Probable). The cytoplasmic dynein 1 complex
CC       consists of two catalytic heavy chains (HCs) and a number of non-
CC       catalytic subunits presented by intermediate chains (ICs), light
CC       intermediate chains (LICs) and light chains (LCs); the composition
CC       seems to vary in respect to the IC, LIC and LC composition. The heavy
CC       chain homodimer serves as a scaffold for the probable homodimeric
CC       assembly of the respective non-catalytic subunits. The ICs and LICs
CC       bind directly to the HC dimer and the LCs assemble on the IC dimer.
CC       Interacts with DYNC1I1 and DYNC1I2. Self-associates. Interacts with
CC       DYNLRB1 (By similarity). {ECO:0000250, ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GAMAD family. {ECO:0000305}.
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DR   EMBL; BC108217; AAI08218.1; -; mRNA.
DR   RefSeq; NP_001070587.1; NM_001077119.2.
DR   AlphaFoldDB; Q32P85; -.
DR   SMR; Q32P85; -.
DR   STRING; 9913.ENSBTAP00000023603; -.
DR   PaxDb; Q32P85; -.
DR   PRIDE; Q32P85; -.
DR   Ensembl; ENSBTAT00000023603; ENSBTAP00000023603; ENSBTAG00000017752.
DR   GeneID; 768062; -.
DR   KEGG; bta:768062; -.
DR   CTD; 83657; -.
DR   VEuPathDB; HostDB:ENSBTAG00000017752; -.
DR   VGNC; VGNC:28277; DYNLRB2.
DR   eggNOG; KOG4115; Eukaryota.
DR   GeneTree; ENSGT00390000011067; -.
DR   HOGENOM; CLU_113002_3_2_1; -.
DR   InParanoid; Q32P85; -.
DR   OMA; PVTIIRH; -.
DR   OrthoDB; 1512428at2759; -.
DR   TreeFam; TF315165; -.
DR   Proteomes; UP000009136; Chromosome 18.
DR   Bgee; ENSBTAG00000017752; Expressed in semen and 106 other tissues.
DR   ExpressionAtlas; Q32P85; baseline and differential.
DR   GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005868; C:cytoplasmic dynein complex; ISS:UniProtKB.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0045505; F:dynein intermediate chain binding; IBA:GO_Central.
DR   GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR   InterPro; IPR016561; DYNLRB1/2.
DR   InterPro; IPR004942; Roadblock/LAMTOR2_dom.
DR   Pfam; PF03259; Robl_LC7; 1.
DR   PIRSF; PIRSF009998; DLC7; 1.
DR   SMART; SM00960; Robl_LC7; 1.
PE   3: Inferred from homology;
KW   Acetylation; Cytoplasm; Cytoskeleton; Dynein; Microtubule; Motor protein;
KW   Reference proteome; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TF09"
FT   CHAIN           2..96
FT                   /note="Dynein light chain roadblock-type 2"
FT                   /id="PRO_0000273562"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TF09"
SQ   SEQUENCE   96 AA;  10846 MW;  41F2B1F0A5F14330 CRC64;
     MAEVEETLKR IQSHKGVIGT MVVNAEGIPI RTTLDNSTTV QYAGLLHQLT MKAKSTVRDI
     DPQNDLTFLR IRSKKHEIMV APDKEYLLIV IQNPCE