ID   DLT1_ASHGO              Reviewed;         274 AA.
AC   Q753V6;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Defect at low temperature protein 1;
GN   Name=DLT1; OrderedLocusNames=AFR219C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Required for growth under high-pressure and low-temperature
CC       conditions. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the DLT1 family. {ECO:0000305}.
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DR   EMBL; AE016819; AAS53590.1; -; Genomic_DNA.
DR   RefSeq; NP_985766.1; NM_211120.1.
DR   AlphaFoldDB; Q753V6; -.
DR   STRING; 33169.AAS53590; -.
DR   EnsemblFungi; AAS53590; AAS53590; AGOS_AFR219C.
DR   GeneID; 4622028; -.
DR   KEGG; ago:AGOS_AFR219C; -.
DR   eggNOG; ENOG502RAJJ; Eukaryota.
DR   HOGENOM; CLU_066044_0_0_1; -.
DR   InParanoid; Q753V6; -.
DR   OMA; DRFKFQG; -.
DR   Proteomes; UP000000591; Chromosome VI.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR038869; DLT1.
DR   PANTHER; PTHR40021; PTHR40021; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..274
FT                   /note="Defect at low temperature protein 1"
FT                   /id="PRO_0000399019"
FT   TOPO_DOM        1..13
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        35..43
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        65..274
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   274 AA;  30984 MW;  930A1DBC78A0D5CD CRC64;
     MGAVNIPTWA RHSFATVLIL LLLAFSLILP VDVIRRVSQM PHEILNTAII VGAAITLLIT
     FTSLSFGRLL VHRSCMQDIP KRYVPITERD LPNTRIRGEI YHKLEHCKQL AHDFSTPETR
     VVHAGLEPPA HVDHCGDDML PPLLDYQACV KIIADRFKFQ GILLNKYMLE PKLGMTFAAQ
     LRRTVSENDC VDRNQLEEFI TLYETIRYSG HPVTRGKFIR FMELCLLLVD FSLLTHRVDT
     PPSGEPSSTT DSATNFNAHV LYSRTEESIS QSSA