ID   DLT1_KLULA              Reviewed;         326 AA.
AC   Q6CJM3;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Defect at low temperature protein 1;
GN   Name=DLT1; OrderedLocusNames=KLLA0F17501g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for growth under high-pressure and low-temperature
CC       conditions. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the DLT1 family. {ECO:0000305}.
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DR   EMBL; CR382126; CAG98574.1; -; Genomic_DNA.
DR   RefSeq; XP_455866.1; XM_455866.1.
DR   AlphaFoldDB; Q6CJM3; -.
DR   STRING; 28985.XP_455866.1; -.
DR   EnsemblFungi; CAG98574; CAG98574; KLLA0_F17501g.
DR   GeneID; 2895608; -.
DR   KEGG; kla:KLLA0_F17501g; -.
DR   eggNOG; ENOG502RAJJ; Eukaryota.
DR   HOGENOM; CLU_066044_0_0_1; -.
DR   InParanoid; Q6CJM3; -.
DR   OMA; DRFKFQG; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR038869; DLT1.
DR   PANTHER; PTHR40021; PTHR40021; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS00430; TONB_DEPENDENT_REC_1; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..326
FT                   /note="Defect at low temperature protein 1"
FT                   /id="PRO_0000399021"
FT   TOPO_DOM        1..13
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        35..45
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        67..326
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          276..306
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        276..294
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   326 AA;  37852 MW;  4E19315DB96CFF98 CRC64;
     MVTSWYKIWY HTTQVIFILL FVGFSVVVPL DCIVQASDSS NDAVNTFIVV GAAVVLVVFG
     ISISFARVLI FRRSLQDIPK KYIPVTAQDM RHKPSREYVI ENMKRAGELA EKFKVPKEPV
     LHAGMEPKDS DMFPEHLKYA EIVKFISDRF RFDGALLLNF VTESDLSTTF KTALHKLFEN
     EKHPYKQYLD EFISLYEKFR FSGQDIERND FVKFLRLYKY LADLSNNLDL TRIESVPSQF
     LHVPTEDYDT DARSRTDSEF STPYLRPYPS DAFMHNTTPA SHVGSRSSNF SYDIDESAEP
     PESVEDQQRY HDMLTRVDTY NTVIHR