ID   DLT1_LACTC              Reviewed;         355 AA.
AC   C5DI25;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Defect at low temperature protein 1;
GN   Name=DLT1; OrderedLocusNames=KLTH0E09152g;
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: Required for growth under high-pressure and low-temperature
CC       conditions. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the DLT1 family. {ECO:0000305}.
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DR   EMBL; CU928169; CAR23436.1; -; Genomic_DNA.
DR   RefSeq; XP_002553873.1; XM_002553827.1.
DR   AlphaFoldDB; C5DI25; -.
DR   SMR; C5DI25; -.
DR   STRING; 559295.C5DI25; -.
DR   EnsemblFungi; CAR23436; CAR23436; KLTH0E09152g.
DR   GeneID; 8292036; -.
DR   KEGG; lth:KLTH0E09152g; -.
DR   eggNOG; ENOG502RAJJ; Eukaryota.
DR   HOGENOM; CLU_066044_0_0_1; -.
DR   InParanoid; C5DI25; -.
DR   OrthoDB; 1410158at2759; -.
DR   Proteomes; UP000002036; Chromosome E.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR038869; DLT1.
DR   PANTHER; PTHR40021; PTHR40021; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..355
FT                   /note="Defect at low temperature protein 1"
FT                   /id="PRO_0000399022"
FT   TOPO_DOM        1..15
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        37..47
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        48..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        69..355
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          236..255
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   355 AA;  39515 MW;  CC107CCCE0F1C21F CRC64;
     MNGDEKLGIW LYRTSLVVLV LFFVGFSVVV PIDAMAQASR STNDALNTFI VVGAFVAFGV
     LSIIIAVGRV LVQRSCLQDI PKGYLPITPE DMPHQPSRSM ILEQMDRSHK LAVLLKKPKE
     PVTHDGLARP DSDDHGLPPL LNYEDSIKII TSRLKYQGVF SNLVKLDSDT GDTFATIARS
     MSAQNKLSSS EAAEYIKLYE AIRFSGKEIT KEQFLQFMDR SIFFLDSLIS TGSIEPRSHR
     AGDGQKNYSF PPTRAQNTLT TPLQQYVTDY ADNESVDTTN IIFPRSPDYA LESSSALHYL
     TTTNTSSTVA RKVTPSSYRK DFSGLNETAS EEAFRGNNHL KLNDNESYDS VVKRC