ID   DLT1_VANPO              Reviewed;         348 AA.
AC   A7TKT6;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Defect at low temperature protein 1;
GN   Name=DLT1; ORFNames=Kpol_1025p10;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: Required for growth under high-pressure and low-temperature
CC       conditions. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the DLT1 family. {ECO:0000305}.
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DR   EMBL; DS480410; EDO17091.1; -; Genomic_DNA.
DR   RefSeq; XP_001644949.1; XM_001644899.1.
DR   AlphaFoldDB; A7TKT6; -.
DR   STRING; 436907.A7TKT6; -.
DR   EnsemblFungi; EDO17091; EDO17091; Kpol_1025p10.
DR   GeneID; 5545282; -.
DR   KEGG; vpo:Kpol_1025p10; -.
DR   eggNOG; ENOG502RAJJ; Eukaryota.
DR   HOGENOM; CLU_066044_0_0_1; -.
DR   InParanoid; A7TKT6; -.
DR   OMA; DRFKFQG; -.
DR   OrthoDB; 1410158at2759; -.
DR   PhylomeDB; A7TKT6; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR038869; DLT1.
DR   PANTHER; PTHR40021; PTHR40021; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..348
FT                   /note="Defect at low temperature protein 1"
FT                   /id="PRO_0000399023"
FT   TOPO_DOM        1..14
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        36..47
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        48..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        69..348
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   348 AA;  39447 MW;  0619472FDD5F0BAE CRC64;
     MTGISLLWLW SKRGFIFISY VFLVCFAAVL PIDSIAQASQ SSNNALNTFI VVGALVIFAV
     VCIILIVGRS LYFKSCLQDV PRRYIPSTAI DLPHRGSREL VTQGVEASKQ LSTMFIKPKD
     PVIHPGVEPP ERCDDPNIDK VFPEYLNYHS CIKNIADRFK YKGVFMSVDK NKLDIDSTFS
     DIVREKYIIS NENVAVKQNA ERLIELYEVL RFSGNPITRE QFVYFVELCI YLVEHSLTHH
     IEEDLTKFPS NTMFSIGEFS TGLQASRIQS RYSAAQSFEN DFGENLLNAQ LSELLQNKSR
     IEEERLGRLR RLAGSINESE DEAISSSISR WNTSSGSITN SYSTVVRH