ADC_BURM1
ID ADC_BURM1 Reviewed; 246 AA.
AC A9AR15;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Acetoacetate decarboxylase {ECO:0000255|HAMAP-Rule:MF_00597};
DE Short=AAD {ECO:0000255|HAMAP-Rule:MF_00597};
DE Short=ADC {ECO:0000255|HAMAP-Rule:MF_00597};
DE EC=4.1.1.4 {ECO:0000255|HAMAP-Rule:MF_00597};
GN Name=adc {ECO:0000255|HAMAP-Rule:MF_00597};
GN OrderedLocusNames=Bmul_5311, BMULJ_03210;
OS Burkholderia multivorans (strain ATCC 17616 / 249).
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX NCBI_TaxID=395019;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 17616 / 249;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Tiedje J.,
RA Richardson P.;
RT "Complete sequence of chromosome 2 of Burkholderia multivorans ATCC
RT 17616.";
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 17616 / 249;
RA Ohtsubo Y., Yamashita A., Kurokawa K., Takami H., Yuhara S., Nishiyama E.,
RA Endo R., Miyazaki R., Ono A., Yano K., Ito M., Sota M., Yuji N.,
RA Hattori M., Tsuda M.;
RT "Complete genome sequence of Burkholderia multivorans ATCC 17616.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the conversion of acetoacetate to acetone and
CC carbon dioxide. {ECO:0000255|HAMAP-Rule:MF_00597}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetoacetate + H(+) = acetone + CO2; Xref=Rhea:RHEA:19729,
CC ChEBI:CHEBI:13705, ChEBI:CHEBI:15347, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526; EC=4.1.1.4; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00597};
CC -!- SIMILARITY: Belongs to the ADC family. {ECO:0000255|HAMAP-
CC Rule:MF_00597}.
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DR EMBL; CP000869; ABX18981.1; -; Genomic_DNA.
DR EMBL; AP009386; BAG45084.1; -; Genomic_DNA.
DR RefSeq; WP_006404627.1; NC_010805.1.
DR AlphaFoldDB; A9AR15; -.
DR SMR; A9AR15; -.
DR STRING; 395019.Bmul_5311; -.
DR EnsemblBacteria; BAG45084; BAG45084; BMULJ_03210.
DR GeneID; 66528251; -.
DR KEGG; bmj:BMULJ_03210; -.
DR KEGG; bmu:Bmul_5311; -.
DR eggNOG; COG4689; Bacteria.
DR HOGENOM; CLU_077089_0_0_4; -.
DR OMA; FEVMRMG; -.
DR Proteomes; UP000008815; Chromosome 2.
DR GO; GO:0047602; F:acetoacetate decarboxylase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 2.40.400.10; -; 1.
DR HAMAP; MF_00597; ADC; 1.
DR InterPro; IPR010451; Acetoacetate_decarboxylase.
DR InterPro; IPR023653; Acetoacetate_decarboxylase_bac.
DR InterPro; IPR023375; ADC_dom_sf.
DR Pfam; PF06314; ADC; 1.
DR SUPFAM; SSF160104; SSF160104; 1.
PE 3: Inferred from homology;
KW Decarboxylase; Lyase; Reference proteome; Schiff base.
FT CHAIN 1..246
FT /note="Acetoacetate decarboxylase"
FT /id="PRO_1000129877"
FT ACT_SITE 116
FT /note="Schiff-base intermediate with acetoacetate"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00597"
SQ SEQUENCE 246 AA; 27396 MW; CED15F54DD164B19 CRC64;
MKISDVRSKA FAMPLTSPAF PMGPYRFVDR EFLIITYRTD PDRLREIVPE PLKVTEPLVH
YEFIRMADST GFGDYTESGQ VIPVEYNGQP GGYTLAMYLD DHPPIAGGRE LWGFPKKLAS
PTLHVNTDHI LGTLDYGKVR VATGTMGYKH KELDIVEQAK RLAGPNFLLK IIPHVDGTAR
VCELVRYYMQ DIVMKGAWTG PASLELSPHA LAPVADLPVL EIVEARHLVA DLTLGLGEVV
YDYLAQ
