DLTC_STRMU
ID DLTC_STRMU Reviewed; 79 AA.
AC O70055;
DT 11-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=D-alanyl carrier protein {ECO:0000255|HAMAP-Rule:MF_00565};
DE Short=DCP {ECO:0000255|HAMAP-Rule:MF_00565};
DE AltName: Full=D-alanine--poly(phosphoribitol) ligase subunit 2 {ECO:0000255|HAMAP-Rule:MF_00565};
GN Name=dltC {ECO:0000255|HAMAP-Rule:MF_00565}; Synonyms=glg3;
GN OrderedLocusNames=SMU_1689;
OS Streptococcus mutans serotype c (strain ATCC 700610 / UA159).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=210007;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7790069; DOI=10.1128/iai.63.7.2556-2563.1995;
RA Spatafora G., Rohrer K., Barnard D., Michalek S.;
RT "A Streptococcus mutans mutant that synthesizes elevated levels of
RT intracellular polysaccharide is hypercariogenic in vivo.";
RL Infect. Immun. 63:2556-2563(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=LT11;
RX PubMed=11029425; DOI=10.1128/jb.182.21.6055-6065.2000;
RA Boyd D.A., Cvitkovitch D.G., Bleiweis A.S., Kiriukhin M.Y., Debabov D.V.,
RA Neuhaus F.C., Hamilton I.R.;
RT "Defects in D-alanyl-lipoteichoic acid synthesis in Streptococcus mutans
RT results in acid sensitivity.";
RL J. Bacteriol. 182:6055-6065(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700610 / UA159;
RX PubMed=12397186; DOI=10.1073/pnas.172501299;
RA Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B.,
RA Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S.,
RA Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J.;
RT "Genome sequence of Streptococcus mutans UA159, a cariogenic dental
RT pathogen.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002).
CC -!- FUNCTION: Carrier protein involved in the D-alanylation of lipoteichoic
CC acid (LTA). The loading of thioester-linked D-alanine onto DltC is
CC catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-
CC carried D-alanyl group is further transferred to cell membrane
CC phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed
CC by DltD. D-alanylation of LTA plays an important role in modulating the
CC properties of the cell wall in Gram-positive bacteria, influencing the
CC net charge of the cell wall. {ECO:0000255|HAMAP-Rule:MF_00565}.
CC -!- PATHWAY: Cell wall biogenesis; lipoteichoic acid biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00565}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00565}.
CC -!- PTM: 4'-phosphopantetheine is transferred from CoA to a specific serine
CC of apo-DCP. {ECO:0000255|HAMAP-Rule:MF_00565}.
CC -!- SIMILARITY: Belongs to the DltC family. {ECO:0000255|HAMAP-
CC Rule:MF_00565}.
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DR EMBL; AF049357; AAC06286.1; -; Genomic_DNA.
DR EMBL; AF051356; AAC05776.1; -; Genomic_DNA.
DR EMBL; AF050517; AAC29040.1; -; Genomic_DNA.
DR EMBL; AE014133; AAN59326.1; -; Genomic_DNA.
DR RefSeq; NP_722020.1; NC_004350.2.
DR RefSeq; WP_002262584.1; NC_004350.2.
DR AlphaFoldDB; O70055; -.
DR SMR; O70055; -.
DR STRING; 210007.SMU_1689; -.
DR PRIDE; O70055; -.
DR EnsemblBacteria; AAN59326; AAN59326; SMU_1689.
DR GeneID; 66818934; -.
DR KEGG; smu:SMU_1689; -.
DR PATRIC; fig|210007.7.peg.1509; -.
DR eggNOG; COG0236; Bacteria.
DR HOGENOM; CLU_108696_19_0_9; -.
DR OMA; DREQWNT; -.
DR PhylomeDB; O70055; -.
DR UniPathway; UPA00556; -.
DR Proteomes; UP000002512; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0036370; F:D-alanyl carrier activity; IEA:UniProtKB-UniRule.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR GO; GO:0070395; P:lipoteichoic acid biosynthetic process; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.1200.10; -; 1.
DR HAMAP; MF_00565; DltC; 1.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR003230; DltC.
DR InterPro; IPR009081; PP-bd_ACP.
DR Pfam; PF00550; PP-binding; 1.
DR SUPFAM; SSF47336; SSF47336; 1.
DR TIGRFAMs; TIGR01688; dltC; 1.
DR PROSITE; PS50075; CARRIER; 1.
PE 3: Inferred from homology;
KW Cell wall biogenesis/degradation; Cytoplasm; Phosphopantetheine;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..79
FT /note="D-alanyl carrier protein"
FT /id="PRO_0000213111"
FT DOMAIN 1..77
FT /note="Carrier"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00565"
FT MOD_RES 35
FT /note="O-(pantetheine 4'-phosphoryl)serine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00565"
SQ SEQUENCE 79 AA; 8979 MW; F4AD34688091D8EB CRC64;
MDIKSEVLKI IDELFMEDVS DMMDEDLFDA GVLDSMGTVE LIVELENHFD ITVPVSEFGR
DDWNTANKII EGITELRNA
