ID   DLTE_BACSU              Reviewed;         252 AA.
AC   P39577;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 2.
DT   03-AUG-2022, entry version 136.
DE   RecName: Full=Uncharacterized oxidoreductase DltE;
DE            EC=1.-.-.-;
GN   Name=dltE; OrderedLocusNames=BSU38540; ORFNames=ipa-1r;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=7934828; DOI=10.1111/j.1365-2958.1993.tb01963.x;
RA   Glaser P., Kunst F., Arnaud M., Coudart M.P., Gonzales W., Hullo M.-F.,
RA   Ionescu M., Lubochinsky B., Marcelino L., Moszer I., Presecan E.,
RA   Santana M., Schneider E., Schweizer J., Vertes A., Rapoport G., Danchin A.;
RT   "Bacillus subtilis genome project: cloning and sequencing of the 97 kb
RT   region from 325 degrees to 333 degrees.";
RL   Mol. Microbiol. 10:371-384(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   SEQUENCE REVISION TO 169-170.
RX   PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA   Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA   Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT   "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT   168 reference genome a decade later.";
RL   Microbiology 155:1758-1775(2009).
RN   [4]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=7797557; DOI=10.1074/jbc.270.26.15598;
RA   Perego M., Glaser P., Minutello A., Strauch M.A., Leopold K., Fischer W.;
RT   "Incorporation of D-alanine into lipoteichoic acid and wall teichoic acid
RT   in Bacillus subtilis. Identification of genes and regulation.";
RL   J. Biol. Chem. 270:15598-15606(1995).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Cells lacking this gene have no defect in
CC       lipoteichoic acid or wall teichoic acid synthesis.
CC       {ECO:0000269|PubMed:7797557}.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; X73124; CAA51557.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB15880.2; -; Genomic_DNA.
DR   PIR; S39656; S39656.
DR   RefSeq; NP_391733.2; NC_000964.3.
DR   RefSeq; WP_003242574.1; NZ_JNCM01000034.1.
DR   AlphaFoldDB; P39577; -.
DR   SMR; P39577; -.
DR   STRING; 224308.BSU38540; -.
DR   PaxDb; P39577; -.
DR   PRIDE; P39577; -.
DR   DNASU; 937369; -.
DR   EnsemblBacteria; CAB15880; CAB15880; BSU_38540.
DR   GeneID; 937369; -.
DR   KEGG; bsu:BSU38540; -.
DR   PATRIC; fig|224308.179.peg.4173; -.
DR   eggNOG; COG3967; Bacteria.
DR   InParanoid; P39577; -.
DR   OMA; WSMNLRT; -.
DR   PhylomeDB; P39577; -.
DR   BioCyc; BSUB:BSU38540-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; NAD; Oxidoreductase; Reference proteome.
FT   CHAIN           1..252
FT                   /note="Uncharacterized oxidoreductase DltE"
FT                   /id="PRO_0000054658"
FT   ACT_SITE        152
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         9..33
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         139
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        169..170
FT                   /note="QL -> HV (in Ref. 1; CAA51557)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   252 AA;  28273 MW;  EF260B3C48E2FE35 CRC64;
     MKMTNNTVLI TGGSAGIGLE LAKRLLELGN EVIICGRSEA RLAEAKQQLP NIHTKQCDVA
     DRSQREALYE WALKEYPNLN VLVNNAGIQK EIDFKKGTEE LFVDGDEIEL NFQAPVHLSA
     LFTPHLMKQP EAAIVQVTSG LAFNPLAVYP VYCATKAALH SFSLTLRHQL RDTSVEVIEM
     APPMVDTGLN QKSRDKQGLT YRGISSEEYV QYFLDGLKEG KQEITNERVE GLRDATRADY
     DRLFEQMNTQ EN