DLT_DROME
ID DLT_DROME Reviewed; 1240 AA.
AC Q8T626; Q8T627; Q9W084;
DT 16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-FEB-2004, sequence version 2.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Protein disks lost;
DE AltName: Full=Codanin 1 homolog;
DE AltName: Full=Protein vanaso;
GN Name=dlt; Synonyms=VA; ORFNames=CG32315;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS.
RC STRAIN=2b, and Oregon-R;
RX PubMed=12454076; DOI=10.1093/genetics/162.3.1321;
RA Fanara J.J., Robinson K.O., Rollmann S.M., Anholt R.R.H., Mackay T.F.C.;
RT "Vanaso is a candidate quantitative trait gene for Drosophila olfactory
RT behavior.";
RL Genetics 162:1321-1328(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=14667407; DOI=10.1016/s1534-5807(03)00358-7;
RA Pielage J., Stork T., Bunse I., Klaembt C.;
RT "The Drosophila cell survival gene discs lost encodes a cytoplasmic
RT Codanin-1-like protein, not a homolog of tight junction PDZ protein Patj.";
RL Dev. Cell 5:841-851(2003).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-156; SER-166 AND SER-1234,
RP AND IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- FUNCTION: Regulator of cell proliferation and cell survival of
CC differentiated cells independent of cell division. Essential for
CC imaginal disks formation. Not involved in cell polarity.
CC {ECO:0000269|PubMed:14667407}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14667407}.
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed. In larvae, it is expressed
CC in all imaginal disks, salivary glands and weakly expressed in the gut.
CC {ECO:0000269|PubMed:14667407}.
CC -!- DEVELOPMENTAL STAGE: Expressed throughout embryogenesis. Expressed in
CC larvae. {ECO:0000269|PubMed:14667407}.
CC -!- MISCELLANEOUS: Its transcript shares the first untranslated exon with
CC the alpha-Spec transcript, suggesting a common regulation. It was
CC initially identified as a candidate for quantitative trait locus (QTL)
CC that affects olfaction. However, given that the mutant used to identify
CC this gene also affects the alpha-Spec gene, this result is unclear.
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DR EMBL; AF487674; AAM18043.1; -; Genomic_DNA.
DR EMBL; AF487677; AAM18044.1; -; Genomic_DNA.
DR EMBL; AE014296; AAF47570.1; -; Genomic_DNA.
DR EMBL; AY051770; AAK93194.1; -; mRNA.
DR RefSeq; NP_728672.1; NM_167916.3.
DR AlphaFoldDB; Q8T626; -.
DR BioGRID; 70341; 3.
DR DIP; DIP-22407N; -.
DR IntAct; Q8T626; 9.
DR MINT; Q8T626; -.
DR STRING; 7227.FBpp0072673; -.
DR iPTMnet; Q8T626; -.
DR PaxDb; Q8T626; -.
DR PRIDE; Q8T626; -.
DR EnsemblMetazoa; FBtr0072790; FBpp0072673; FBgn0024510.
DR GeneID; 46719; -.
DR KEGG; dme:Dmel_CG32315; -.
DR CTD; 46719; -.
DR FlyBase; FBgn0024510; dlt.
DR VEuPathDB; VectorBase:FBgn0024510; -.
DR eggNOG; ENOG502QPWR; Eukaryota.
DR HOGENOM; CLU_007271_0_0_1; -.
DR InParanoid; Q8T626; -.
DR OMA; CVVKDAQ; -.
DR OrthoDB; 664227at2759; -.
DR PhylomeDB; Q8T626; -.
DR SignaLink; Q8T626; -.
DR BioGRID-ORCS; 46719; 0 hits in 1 CRISPR screen.
DR ChiTaRS; COX5A; fly.
DR GenomeRNAi; 46719; -.
DR PRO; PR:Q8T626; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0024510; Expressed in eye disc (Drosophila) and 25 other tissues.
DR Genevisible; Q8T626; DM.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0006325; P:chromatin organization; IBA:GO_Central.
DR GO; GO:0007560; P:imaginal disc morphogenesis; IMP:UniProtKB.
DR GO; GO:0001738; P:morphogenesis of a polarized epithelium; TAS:FlyBase.
DR GO; GO:0042048; P:olfactory behavior; IEP:FlyBase.
DR GO; GO:0042127; P:regulation of cell population proliferation; IMP:UniProtKB.
DR InterPro; IPR040031; Codanin-1.
DR InterPro; IPR028171; Codanin-1_C.
DR PANTHER; PTHR28678; PTHR28678; 1.
DR Pfam; PF15296; Codanin-1_C; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Phosphoprotein; Reference proteome.
FT CHAIN 1..1240
FT /note="Protein disks lost"
FT /id="PRO_0000079934"
FT REGION 105..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 179..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 156
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 166
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1234
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT VARIANT 136
FT /note="P -> T (in strain: Oregon-R)"
FT VARIANT 209
FT /note="A -> V (in strain: Oregon-R)"
FT VARIANT 358
FT /note="Y -> C (in strain: Oregon-R)"
FT VARIANT 411
FT /note="V -> I (in strain: 2b)"
FT VARIANT 418
FT /note="H -> Y (in strain: 2b)"
FT VARIANT 425
FT /note="S -> L (in strain: 2b and Oregon-R)"
FT VARIANT 734
FT /note="P -> T (in strain: Oregon-R)"
FT VARIANT 958
FT /note="S -> A (in strain: Oregon-R)"
FT VARIANT 1069
FT /note="K -> R (in strain: Oregon-R)"
FT VARIANT 1146
FT /note="A -> G (in strain: Oregon-R)"
FT VARIANT 1167
FT /note="A -> T (in strain: Oregon-R)"
FT VARIANT 1209
FT /note="A -> D (in strain: 2b)"
SQ SEQUENCE 1240 AA; 139459 MW; 753E60743F3077BA CRC64;
MTAELKASDT EMTKPEERHL LQLLAQLEKV PHHQLEQKFV AYFKKVGKGD NQSNCTLEDF
ATYFLGALRQ STKRYYYSQN SETPVFPLTP IHQLKPPVAD VVKEEEQQQL NESSILSRSS
CSMSSTSNTT PAPQQPQGRR STPGSGAQFC STPNRSGGGG AGGGHSICLG NFLVNTPIQS
HQRSKKKITP QKQQQNQHAS LGSGTGAGAT PQSKPRRRVL PMTISKNVSA SSSFGDTSSF
SNENNFWRIS QSSEIFDRSQ EAALEMEARK FLLLKKQEIK SEAPVNVSQQ ERTPEDEVFP
EEAISLEGVA NANHLQLLST IYSLLMDLNL VPNVLRELSF VVHLLNVRDF GQSPVKSYVP
SALEGLTQHK SCVYFAAKLL ENQKKLLLQL DKRTLSVLLQ NERLSLLPQG VVQELETHCQ
RRQDSTTPFA MDTSSSSQQN VYYHVENDSR DNFPSQNEFG AFKSQRDLFY KALKRWEVSH
LNRGFNFPSE LGPRIMDIYK KSEHPVNMTH LAKLFVNQLL ISATETTESP EELGLKLDPL
RHNKLAQRLV TSSSSVEGQF PRSQAFFRDF IAVCSSVAFL VHLKLELFVQ LMRNNDSTFD
LLQLTDDVAV EEQSAQQGPY IVRVQTMANM LILAKFLGYV TVMPFSGTTQ HGNPTPPYLC
PQQLQLRNHF RPDFNLREIL ERSMRQGKLL ITLPWLVQYL AMLDLVSLHL PDAVATLELL
YGLYADIRMA KLQPAAVFIA RSCIGWLLDA QPQLVNGYYN YRAQEAGVGS ISAIVDICLK
DLSCHDKSHA PLLDELLPVA CPFLQEFRVS ITPSRQAKSG RFRYITTRLE QLQQNSSSIS
KDAIVASELS PAEQQQRKLV DAYLQSQNAS TRRLIEFVTE RTFKCVVKDA QQEILLPSKA
SADAKVNEIK STMLEEVFQE LHEIFQDARE NACQRWKEHV HQMLDRRIEH SLDGLLPSST
NAVLRSTYAH LIRVQAQTQL QQWLQSSVLQ STFYHGDLQE LATKVCNCNR NKADAAAAGG
GGSSELQLSP DIGFSLSEFL YQLQQWLHCL SLRPEYVGSQ EDLAELLRKA QKAVLLPKMP
TVFYHLIGSG LVHLLQLLIT RKPNFLDKDI ISASCSVWRS QQLMDSKASP GIFDGLISIS
FVQEMANSAD SFRMLETILR SMLQSGAIRA DHLNELFMPL FAENWSPKVW CMLSELLQQL
SLSGKDSEAH YASGDSPEDE AKSHLFMEML ADLSRDLDNF
