ID   DLX1A_DANRE             Reviewed;         252 AA.
AC   Q98875; Q567K7;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 143.
DE   RecName: Full=Homeobox protein Dlx1a;
DE            Short=DLX-1;
DE   AltName: Full=Distal-less homeobox gene 1a;
GN   Name=dlx1a; Synonyms=dlx1;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Larva;
RX   PubMed=8855272; DOI=10.1073/pnas.93.20.10858;
RA   Stock D.W., Ellies D.L., Zhao Z., Ekker M., Ruddle F.H., Weiss K.M.;
RT   "The evolution of the vertebrate Dlx gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 93:10858-10863(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Larva;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the distal-less homeobox family. {ECO:0000305}.
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DR   EMBL; U67842; AAC60025.1; -; mRNA.
DR   EMBL; BC093139; AAH93139.1; -; mRNA.
DR   RefSeq; NP_571380.1; NM_131305.1.
DR   RefSeq; XP_005167457.1; XM_005167400.3.
DR   AlphaFoldDB; Q98875; -.
DR   SMR; Q98875; -.
DR   STRING; 7955.ENSDARP00000011033; -.
DR   PaxDb; Q98875; -.
DR   Ensembl; ENSDART00000019910; ENSDARP00000011033; ENSDARG00000013125.
DR   GeneID; 30568; -.
DR   KEGG; dre:30568; -.
DR   CTD; 30568; -.
DR   ZFIN; ZDB-GENE-990415-48; dlx1a.
DR   eggNOG; KOG0850; Eukaryota.
DR   GeneTree; ENSGT00940000160029; -.
DR   HOGENOM; CLU_074733_2_0_1; -.
DR   InParanoid; Q98875; -.
DR   OMA; MEFGPPG; -.
DR   OrthoDB; 1416398at2759; -.
DR   PhylomeDB; Q98875; -.
DR   TreeFam; TF315720; -.
DR   PRO; PR:Q98875; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 9.
DR   Bgee; ENSDARG00000013125; Expressed in skeleton of lower jaw and 27 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0051216; P:cartilage development; IGI:ZFIN.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IGI:ZFIN.
DR   GO; GO:0046533; P:negative regulation of photoreceptor cell differentiation; ISS:UniProtKB.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:1902871; P:positive regulation of amacrine cell differentiation; ISS:UniProtKB.
DR   GO; GO:0045597; P:positive regulation of cell differentiation; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..252
FT                   /note="Homeobox protein Dlx1a"
FT                   /id="PRO_0000049046"
FT   DNA_BIND        128..187
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
SQ   SEQUENCE   252 AA;  27686 MW;  CBEAFCEA2B2A9757 CRC64;
     MTMSTIPESL NSPVSGKSVF MEFGPPSQQM SPSSMTHGHY SMHCLHSSGH PQHDSAYSPA
     PSFPRSLPYP YVNSVGSHSS SPYLSTVQTY PNNSALAQTR LEDPAPESEK NTVVEGGEVR
     FNGKGKKIRK PRTIYSSLQL QALNRRFQQT QYLALPERAE LAASLGLTQT QVKIWFQNKR
     SKFKKLMKQG GGTIDTNALA NGRGLSTGSP SVAPVWNTTA TVKTSTPTSY IPSYTSWYPT
     AHQDTMQQPQ LM