ID   DLX1_RAT                Reviewed;          44 AA.
AC   Q64202;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Homeobox protein DLX-1;
DE   Flags: Fragment;
GN   Name=Dlx1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8613727; DOI=10.1523/jneurosci.15-12-07879.1995;
RA   Robel L., Ding M., James A.J., Lin X., Simeone A., Leckman J.F.,
RA   Vaccarino F.M.;
RT   "Fibroblast growth factor 2 increases Otx2 expression in precursor cells
RT   from mammalian telencephalon.";
RL   J. Neurosci. 15:7879-7891(1995).
CC   -!- FUNCTION: Plays a role as a transcriptional activator or repressor.
CC       Inhibits several cytokine signaling pathways, such as TGFB1, activin-
CC       A/INHBA and BMP4 by interfering with the transcriptional stimulatory
CC       activity of transcription factors, such as MSX2, FAST2, SMAD2 and SMAD3
CC       during hematopoietic cell differentiation. Plays a role in terminal
CC       differentiation of interneurons, such as amacrine and bipolar cells in
CC       the developing retina. Likely to play a regulatory role in the
CC       development of the ventral forebrain. May play a role in craniofacial
CC       patterning and morphogenesis and may be involved in the early
CC       development of diencephalic subdivisions.
CC       {ECO:0000250|UniProtKB:P56177, ECO:0000250|UniProtKB:Q64317}.
CC   -!- SUBUNIT: Interacts with SMAD4 (via homeobox DNA-binding domain).
CC       Interacts (via homeobox DNA-binding domain) with POU4F2; this
CC       interaction suppresses DLX1-mediated transcriptional activity in
CC       postnatal retina and enhances retinal ganglion cell (RGC)
CC       differentiation. {ECO:0000250|UniProtKB:P56177,
CC       ECO:0000250|UniProtKB:Q64317}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P56177}.
CC   -!- DOMAIN: The homeobox DNA-binding domain is necessary for its nuclear
CC       localization, transcriptional and erythroid differentiation activities.
CC       {ECO:0000250|UniProtKB:P56177}.
CC   -!- SIMILARITY: Belongs to the distal-less homeobox family. {ECO:0000305}.
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DR   EMBL; S81923; AAP32272.1; -; mRNA.
DR   AlphaFoldDB; Q64202; -.
DR   STRING; 10116.ENSRNOP00000002078; -.
DR   PaxDb; Q64202; -.
DR   UCSC; RGD:1309593; rat.
DR   RGD; 1309593; Dlx1.
DR   eggNOG; KOG0850; Eukaryota.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003682; F:chromatin binding; ISO:RGD.
DR   GO; GO:0003677; F:DNA binding; ISO:RGD.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISO:RGD.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; ISO:RGD.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR   GO; GO:0030154; P:cell differentiation; ISO:RGD.
DR   GO; GO:0071773; P:cellular response to BMP stimulus; ISS:UniProtKB.
DR   GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; ISS:UniProtKB.
DR   GO; GO:0021892; P:cerebral cortex GABAergic interneuron differentiation; ISO:RGD.
DR   GO; GO:0021893; P:cerebral cortex GABAergic interneuron fate commitment; ISO:RGD.
DR   GO; GO:0048706; P:embryonic skeletal system development; ISO:RGD.
DR   GO; GO:0021879; P:forebrain neuron differentiation; ISO:RGD.
DR   GO; GO:0021766; P:hippocampus development; ISO:RGD.
DR   GO; GO:0030514; P:negative regulation of BMP signaling pathway; ISS:UniProtKB.
DR   GO; GO:1903845; P:negative regulation of cellular response to transforming growth factor beta stimulus; ISS:UniProtKB.
DR   GO; GO:0043524; P:negative regulation of neuron apoptotic process; ISO:RGD.
DR   GO; GO:0045746; P:negative regulation of Notch signaling pathway; ISO:RGD.
DR   GO; GO:0048715; P:negative regulation of oligodendrocyte differentiation; ISO:RGD.
DR   GO; GO:0046533; P:negative regulation of photoreceptor cell differentiation; ISS:UniProtKB.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0042475; P:odontogenesis of dentin-containing tooth; ISO:RGD.
DR   GO; GO:1902871; P:positive regulation of amacrine cell differentiation; ISS:UniProtKB.
DR   GO; GO:0045597; P:positive regulation of cell differentiation; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0009954; P:proximal/distal pattern formation; ISO:RGD.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISO:RGD.
DR   GO; GO:0021544; P:subpallium development; ISO:RGD.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; Differentiation; DNA-binding; Homeobox;
KW   Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           <1..>44
FT                   /note="Homeobox protein DLX-1"
FT                   /id="PRO_0000049022"
FT   REGION          19..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT   NON_TER         44
SQ   SEQUENCE   44 AA;  4451 MW;  D62FD1E80FB66F1A CRC64;
     KLMKQGGAAL EGSALANGRA LSAGSPPVPP GWNRIPPLGR AQEE