ID   DLX2A_DANRE             Reviewed;         270 AA.
AC   P50574;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Homeobox protein Dlx2a;
DE            Short=DLX-2;
DE   AltName: Full=Distal-less homeobox gene 2a;
GN   Name=dlx2a; Synonyms=dlx2;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7911517; DOI=10.1523/jneurosci.14-06-03475.1994;
RA   Akimenko M.-A., Ekker M., Wegner J., Lin W., Westerfield M.;
RT   "Combinatorial expression of three zebrafish genes related to distal-less:
RT   part of a homeobox gene code for the head.";
RL   J. Neurosci. 14:3475-3486(1994).
CC   -!- FUNCTION: Involved in the development of the inner ear.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- TISSUE SPECIFICITY: Expressed in the developing forebrain and fins.
CC   -!- DEVELOPMENTAL STAGE: Not expressed during gastrulation, and shortly
CC       after gastrulation found in the cells of the ventral fore-brain
CC       rudiment, and hind-brain neural crest cells. Not expressed in the
CC       auditory vesicles, found in low levels in localized regions of the
CC       median fin fold, and is also expressed by the cells of the visceral
CC       arches and their primordia.
CC   -!- SIMILARITY: Belongs to the distal-less homeobox family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U03875; AAA19826.1; -; mRNA.
DR   PIR; I50111; I50111.
DR   AlphaFoldDB; P50574; -.
DR   SMR; P50574; -.
DR   STRING; 7955.ENSDARP00000103004; -.
DR   PaxDb; P50574; -.
DR   ZFIN; ZDB-GENE-980526-212; dlx2a.
DR   eggNOG; KOG0850; Eukaryota.
DR   InParanoid; P50574; -.
DR   PRO; PR:P50574; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0051216; P:cartilage development; IMP:ZFIN.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IMP:ZFIN.
DR   GO; GO:0046533; P:negative regulation of photoreceptor cell differentiation; ISS:UniProtKB.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0014032; P:neural crest cell development; IMP:ZFIN.
DR   GO; GO:0007422; P:peripheral nervous system development; IMP:ZFIN.
DR   GO; GO:0060037; P:pharyngeal system development; IMP:ZFIN.
DR   GO; GO:1902871; P:positive regulation of amacrine cell differentiation; ISS:UniProtKB.
DR   GO; GO:0045597; P:positive regulation of cell differentiation; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0042254; P:ribosome biogenesis; IMP:ZFIN.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR022135; Distal-less_N.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF12413; DLL_N; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..270
FT                   /note="Homeobox protein Dlx2a"
FT                   /id="PRO_0000049047"
FT   DNA_BIND        123..182
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          19..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   270 AA;  29829 MW;  60BB238163AFEFC3 CRC64;
     MTGVFDSLST DMHSNQITSS SYHSLHKSQE SPTLPVSTAT DSSINNNNQQ CAGSPYGQSS
     SYQYQNNSMN SVQYNTKSYE LGFGNAFGPY GTYGSCSSPT PADAEKEERE PEIRMVNGKP
     KKVRKPRTIY STFQLAALQR RFQKTQYLAL PERAELAASL GLTQTQVKIW FQNRRSKFKK
     LWKSGEIPPE QHVASGESPP HPSPPLAAAW DFAHSQRMNT VNSGLSQSSP PNSTTPSFLT
     NYPWYSSTNS AAHLQPPLHH NTTVSAGTIF