ID   DLX2B_DANRE             Reviewed;         276 AA.
AC   Q98876;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 135.
DE   RecName: Full=Homeobox protein Dlx2b;
DE   AltName: Full=DLX-5;
DE   AltName: Full=Distal-less homeobox protein 2b;
GN   Name=dlx2b; Synonyms=dlx5;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Larva;
RX   PubMed=8855272; DOI=10.1073/pnas.93.20.10858;
RA   Stock D.W., Ellies D.L., Zhao Z., Ekker M., Ruddle F.H., Weiss K.M.;
RT   "The evolution of the vertebrate Dlx gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 93:10858-10863(1996).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the distal-less homeobox family. {ECO:0000305}.
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DR   EMBL; U67843; AAC60026.1; -; mRNA.
DR   RefSeq; NP_571372.1; NM_131297.2.
DR   AlphaFoldDB; Q98876; -.
DR   SMR; Q98876; -.
DR   STRING; 7955.ENSDARP00000007080; -.
DR   PaxDb; Q98876; -.
DR   Ensembl; ENSDART00000008469; ENSDARP00000007080; ENSDARG00000017174.
DR   Ensembl; ENSDART00000183351; ENSDARP00000148270; ENSDARG00000116017.
DR   GeneID; 30557; -.
DR   KEGG; dre:30557; -.
DR   CTD; 30557; -.
DR   ZFIN; ZDB-GENE-980526-18; dlx2b.
DR   eggNOG; KOG0850; Eukaryota.
DR   GeneTree; ENSGT00940000160127; -.
DR   HOGENOM; CLU_074733_1_1_1; -.
DR   InParanoid; Q98876; -.
DR   OMA; PHHSSAM; -.
DR   OrthoDB; 1416398at2759; -.
DR   PhylomeDB; Q98876; -.
DR   TreeFam; TF350606; -.
DR   PRO; PR:Q98876; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 1.
DR   Bgee; ENSDARG00000017174; Expressed in caudal fin and 6 other tissues.
DR   ExpressionAtlas; Q98876; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0048731; P:system development; IEA:UniProt.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR022135; Distal-less_N.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF12413; DLL_N; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..276
FT                   /note="Homeobox protein Dlx2b"
FT                   /id="PRO_0000049048"
FT   DNA_BIND        125..184
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          97..123
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          191..238
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        105..121
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        214..238
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   276 AA;  29965 MW;  56147D893F614064 CRC64;
     MTAVLDSLGS DMHTNHITSS SFSTVHKSQD SPTLPVSTVT DSSFFSSSQT GHCAGTAYAQ
     LASYSYHPGT VGNVHYSPKA YDLGYASSYG AYGTYGASSS PTPTEPEKEE SEPEVRMVNG
     KPKKVRKPRT IYSSFQLAAL QRRFQKTQYL ALPERAELAA SLGLTQTQVK IWFQNRRSKF
     KKLWKNGEIP ADQQVASGDS PSSSPPPQAG WDFPPNPTQN DGDTVSEQPT GPPNTTAPSF
     LTNYSWYSST NAVTHLQPST LIQPHHSSAM STGTIF