DLX3B_DANRE
ID DLX3B_DANRE Reviewed; 269 AA.
AC Q01702;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Homeobox protein Dlx3b;
DE Short=DLX-3;
DE AltName: Full=Distal-less homeobox protein 3b;
GN Name=dlx3b; Synonyms=dlx3;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=AB; TISSUE=Embryo;
RX PubMed=1352984; DOI=10.1016/0896-6273(92)90217-2;
RA Ekker M., Akimenko M.-A., Bremiller R., Westerfield M.;
RT "Regional expression of three homeobox transcripts in the inner ear of
RT zebrafish embryos.";
RL Neuron 9:27-35(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=AB; TISSUE=Embryo;
RX PubMed=7911517; DOI=10.1523/jneurosci.14-06-03475.1994;
RA Akimenko M.-A., Ekker M., Wegner J., Lin W., Westerfield M.;
RT "Combinatorial expression of three zebrafish genes related to distal-less:
RT part of a homeobox gene code for the head.";
RL J. Neurosci. 14:3475-3486(1994).
CC -!- FUNCTION: Involved in the development of the inner ear.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- TISSUE SPECIFICITY: Expressed in the developing forebrain and fins.
CC -!- DEVELOPMENTAL STAGE: Expressed during gastrulation, and shortly after
CC gastrulation is expressed by presumptive precursor cells of the
CC olfactory placodes, overlapping subsets of cells in the auditory
CC vesicle, cells of the median fin fold, and cells of the visceral arches
CC and their primordia.
CC -!- SIMILARITY: Belongs to the distal-less homeobox family. {ECO:0000305}.
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DR EMBL; X65060; CAA46193.1; -; Genomic_DNA.
DR PIR; S23279; S23279.
DR AlphaFoldDB; Q01702; -.
DR SMR; Q01702; -.
DR STRING; 7955.ENSDARP00000022291; -.
DR PaxDb; Q01702; -.
DR ZFIN; ZDB-GENE-980526-280; dlx3b.
DR eggNOG; KOG0850; Eukaryota.
DR InParanoid; Q01702; -.
DR PRO; PR:Q01702; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IPI:ZFIN.
DR GO; GO:0042667; P:auditory receptor cell fate specification; IGI:ZFIN.
DR GO; GO:0043010; P:camera-type eye development; IGI:ZFIN.
DR GO; GO:0051216; P:cartilage development; IGI:ZFIN.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IGI:ZFIN.
DR GO; GO:0035270; P:endocrine system development; IGI:ZFIN.
DR GO; GO:0030855; P:epithelial cell differentiation; IBA:GO_Central.
DR GO; GO:0060119; P:inner ear receptor cell development; IGI:ZFIN.
DR GO; GO:0070306; P:lens fiber cell differentiation; IGI:ZFIN.
DR GO; GO:0048666; P:neuron development; IGI:ZFIN.
DR GO; GO:0071698; P:olfactory placode development; IMP:ZFIN.
DR GO; GO:0030910; P:olfactory placode formation; IGI:ZFIN.
DR GO; GO:0043049; P:otic placode formation; IMP:ZFIN.
DR GO; GO:0071599; P:otic vesicle development; IMP:ZFIN.
DR GO; GO:0030916; P:otic vesicle formation; IMP:ZFIN.
DR GO; GO:0071600; P:otic vesicle morphogenesis; IGI:ZFIN.
DR GO; GO:0048840; P:otolith development; IMP:ZFIN.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0021559; P:trigeminal nerve development; IGI:ZFIN.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR022135; Distal-less_N.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR000047; HTH_motif.
DR Pfam; PF12413; DLL_N; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..269
FT /note="Homeobox protein Dlx3b"
FT /id="PRO_0000049049"
FT DNA_BIND 125..184
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 250..269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..228
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 269 AA; 30419 MW; 42087C60FB041582 CRC64;
MSGPTYDRKI PGISTDLSGS MSCHPTSKDS PTLPESSATD MGYYSSHHEY YQSPPYPQQM
NSYHQFNLSG MGATPGAYPT KTEYPYNTYR QYGHFNRDLQ TPPQSAVKEE PETEVRMVNG
KPKKIRKPRT IYSSYQLAAL QRRFQKAQYL ALPERAELAA QLGLTQTQVK IWFQNRRSKF
KKLYKNGEVP LEHSPNASDS MACNSPPSPA VWDNNAHSSQ VNRGQIPQPP LSSTPPYMED
YSNHWYQQGS HLQHPVHHPG PPQSVGAVY
