ID   DLX3_AMBME              Reviewed;         280 AA.
AC   Q90229;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Homeobox protein DLX-3;
GN   Name=DLX-3;
OS   Ambystoma mexicanum (Axolotl).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Caudata; Salamandroidea; Ambystomatidae; Ambystoma.
OX   NCBI_TaxID=8296;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8951064; DOI=10.1242/dev.122.11.3487;
RA   Mullen L.M., Bryant S.V., Torok M.A., Blumberg B., Gardiner D.M.;
RT   "Nerve dependency of regeneration: the role of Distal-less and FGF
RT   signaling in amphibian limb regeneration.";
RL   Development 122:3487-3497(1996).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the distal-less homeobox family. {ECO:0000305}.
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DR   EMBL; U59480; AAB49668.1; -; mRNA.
DR   AlphaFoldDB; Q90229; -.
DR   SMR; Q90229; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR022135; Distal-less_N.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF12413; DLL_N; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus.
FT   CHAIN           1..280
FT                   /note="Homeobox protein DLX-3"
FT                   /id="PRO_0000049040"
FT   DNA_BIND        126..185
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          189..252
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        212..230
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        231..252
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   280 AA;  31201 MW;  0F8183097ABAC791 CRC64;
     MSTILTDLSS SLSCHAASKD SPTLPESSAT DLGYYSTHGG THSPHDYFQS QPYPQPINHH
     YPYHQFNLNG LGGPGTYSPK SDYPYGGSYR QYGHYRESAM AVQEPVSVKE EPEPEVRMVN
     GKPKKIRKPR TIYSSYQLAA LQRRFQKAQY LALPERAELA AQLGLTQTQV KIWFQNRRSK
     FKKLYKNGEV PGMEHSPDNS DSMACNSPAS PPVWDSNPPS RVPHPQAQPL PHNSSPSYLE
     DYNPGTTMNR TWRGTPAAAQ LDAPYPSGTG SVLAGCWWKN