DLX3_MOUSE
ID DLX3_MOUSE Reviewed; 287 AA.
AC Q64205;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Homeobox protein DLX-3;
GN Name=Dlx3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=FVB/N;
RX PubMed=7893603; DOI=10.1016/0925-4773(94)90060-4;
RA Robinson G.W., Mahon K.A.;
RT "Differential and overlapping expression domains of Dlx-2 and Dlx-3 suggest
RT distinct roles for Distal-less homeobox genes in craniofacial
RT development.";
RL Mech. Dev. 48:199-215(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Likely to play a regulatory role in the development of the
CC ventral forebrain. May play a role in craniofacial patterning and
CC morphogenesis.
CC -!- SUBUNIT: Heterodimer with MEIS1. {ECO:0000250|UniProtKB:O60479}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- TISSUE SPECIFICITY: Not expressed in the central nervous system.
CC Expressed in a highly restricted region of the branchial arches. In
CC later development, expressed in the developing middle and inner ear,
CC teeth and whisker follicles.
CC -!- SIMILARITY: Belongs to the distal-less homeobox family. {ECO:0000305}.
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DR EMBL; S81932; AAB33879.1; -; mRNA.
DR EMBL; BC058852; AAH58852.1; -; mRNA.
DR CCDS; CCDS25272.1; -.
DR RefSeq; NP_034185.1; NM_010055.3.
DR AlphaFoldDB; Q64205; -.
DR SMR; Q64205; -.
DR STRING; 10090.ENSMUSP00000090443; -.
DR iPTMnet; Q64205; -.
DR PhosphoSitePlus; Q64205; -.
DR PaxDb; Q64205; -.
DR PRIDE; Q64205; -.
DR ProteomicsDB; 279386; -.
DR Antibodypedia; 17996; 259 antibodies from 32 providers.
DR DNASU; 13393; -.
DR Ensembl; ENSMUST00000092768; ENSMUSP00000090443; ENSMUSG00000001510.
DR GeneID; 13393; -.
DR KEGG; mmu:13393; -.
DR UCSC; uc007kzy.2; mouse.
DR CTD; 1747; -.
DR MGI; MGI:94903; Dlx3.
DR VEuPathDB; HostDB:ENSMUSG00000001510; -.
DR eggNOG; KOG0850; Eukaryota.
DR GeneTree; ENSGT00940000158951; -.
DR HOGENOM; CLU_074733_1_0_1; -.
DR InParanoid; Q64205; -.
DR OMA; SWYHTQN; -.
DR OrthoDB; 1416398at2759; -.
DR PhylomeDB; Q64205; -.
DR TreeFam; TF350606; -.
DR BioGRID-ORCS; 13393; 3 hits in 74 CRISPR screens.
DR ChiTaRS; Dlx3; mouse.
DR PRO; PR:Q64205; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q64205; protein.
DR Bgee; ENSMUSG00000001510; Expressed in calcareous tooth and 155 other tissues.
DR ExpressionAtlas; Q64205; baseline and differential.
DR Genevisible; Q64205; MM.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0003682; F:chromatin binding; IDA:MGI.
DR GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0001568; P:blood vessel development; IMP:MGI.
DR GO; GO:0030509; P:BMP signaling pathway; IMP:MGI.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0030855; P:epithelial cell differentiation; IBA:GO_Central.
DR GO; GO:0010467; P:gene expression; IMP:MGI.
DR GO; GO:0035315; P:hair cell differentiation; IMP:MGI.
DR GO; GO:0042633; P:hair cycle; IMP:MGI.
DR GO; GO:0071335; P:hair follicle cell proliferation; IMP:MGI.
DR GO; GO:0001942; P:hair follicle development; IMP:MGI.
DR GO; GO:0031069; P:hair follicle morphogenesis; IMP:MGI.
DR GO; GO:0071895; P:odontoblast differentiation; IMP:CACAO.
DR GO; GO:0042475; P:odontogenesis of dentin-containing tooth; IMP:MGI.
DR GO; GO:0001890; P:placenta development; IMP:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0016055; P:Wnt signaling pathway; IMP:MGI.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR022135; Distal-less_N.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR000047; HTH_motif.
DR Pfam; PF12413; DLL_N; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..287
FT /note="Homeobox protein DLX-3"
FT /id="PRO_0000049027"
FT DNA_BIND 129..188
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 131..181
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250|UniProtKB:O60479"
FT REGION 195..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..240
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..287
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 287 AA; 31791 MW; 1F7DB917FC4C2158 CRC64;
MSGSFDRKLS SILTDISSSL SCHAGSKDSP TLPESTVTDL GYYSAPQHDY YSGQPYGQTV
NPYTYHHQFN LNGLAGTGAY SPKSEYTYGG SYRQYGAYRE QPLPAQDPVS VKEEPEAEVR
MVNGKPKKVR KPRTIYSSYQ LAALQRRFQK AQYLALPERA ELAAQLGLTQ TQVKIWFQNR
RSKFKKLYKN GEVPLEHSPN NSDSMACNSP PSPALWDTSS HSTPAPARNP LPPPLPYSAS
PNYLDDPTNS WYHTQNLSGP HLQQQPPQPA TLHHASPGPP PNPGAVY
