ID   DLX3_NOTVI              Reviewed;         273 AA.
AC   P53770;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Homeobox protein DLX-3;
DE   AltName: Full=Box-4;
DE   AltName: Full=NvHbox-4;
GN   Name=DLX3; Synonyms=BOX4;
OS   Notophthalmus viridescens (Eastern newt) (Triturus viridescens).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Caudata; Salamandroidea; Salamandridae; Pleurodelinae;
OC   Notophthalmus.
OX   NCBI_TaxID=8316;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Skin;
RX   PubMed=1358728; DOI=10.1016/0012-1606(92)90047-k;
RA   Beauchemin M., Savard P.;
RT   "Two distal-less related homeobox-containing genes expressed in
RT   regeneration blastemas of the newt.";
RL   Dev. Biol. 154:55-65(1992).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- TISSUE SPECIFICITY: Expressed in regeneration blastemas. Detected in
CC       forelimbs, hindlimbs, the tail, flank, and brain as well as in limb and
CC       tail blastemas.
CC   -!- SIMILARITY: Belongs to the distal-less homeobox family. {ECO:0000305}.
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DR   EMBL; X63531; CAA45094.1; -; mRNA.
DR   PIR; B48820; B48820.
DR   AlphaFoldDB; P53770; -.
DR   SMR; P53770; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR022135; Distal-less_N.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF12413; DLL_N; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus.
FT   CHAIN           1..273
FT                   /note="Homeobox protein DLX-3"
FT                   /id="PRO_0000049043"
FT   DNA_BIND        125..184
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          15..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          188..235
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          248..273
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        198..235
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   273 AA;  30654 MW;  B356D01233061F2F CRC64;
     MTTILTDLSS SLSCHAASKD SPTLPESSAT DLGYYSTHGG THSPHDYYQN QPYSQPISHY
     PYHQFNLNGL GGPGTYSPKS EYPYGGGYRQ YGHYREPAMA VQEPVTVKEE PEPEVRMVNG
     KPKKIRKPRT IYSSYQLAAL QRRFQKAQYL ALPERAELAA QLGLTQTQVK IWFQNRRSKF
     KKLYKNGEVP GMEHSPDNSD SMACNSPASP TVWDNNTPSR VQHTQAQPLP HNSSPSYLED
     YNPWYHHPQN LSGPHLQPPG TMHHTPPGTG AVY