ID   DLX3_PLEWA              Reviewed;         274 AA.
AC   Q91284;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Distal-less-like protein DLX-3;
GN   Name=DLX3;
OS   Pleurodeles waltl (Iberian ribbed newt).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Caudata; Salamandroidea; Salamandridae; Pleurodelinae;
OC   Pleurodeles.
OX   NCBI_TaxID=8319;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8798159; DOI=10.1016/0925-4773(96)00535-7;
RA   Nicolas S., Massacrier A., Caubit X., Cau P., le Parco Y.;
RT   "A Distal-less-like gene is induced in the regenerating central nervous
RT   system of the urodele Pleurodeles waltl.";
RL   Mech. Dev. 56:209-220(1996).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in the regenerating spinal cord but not
CC       in the adult one.
CC   -!- SIMILARITY: Belongs to the distal-less homeobox family. {ECO:0000305}.
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DR   EMBL; U49645; AAA98645.1; -; mRNA.
DR   AlphaFoldDB; Q91284; -.
DR   SMR; Q91284; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR022135; Distal-less_N.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF12413; DLL_N; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus.
FT   CHAIN           1..274
FT                   /note="Distal-less-like protein DLX-3"
FT                   /id="PRO_0000049044"
FT   DNA_BIND        126..185
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          189..274
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        199..240
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   274 AA;  30607 MW;  94148553BA80B8C8 CRC64;
     MTTILTDLSS SLSCHAASKD SPTLPESSAT DLGYYSAHAG THSPHDYFQS QPYSQPISHY
     PYHQFNLNGL GGPGTYSPKS EYPYGGGGYR QYGHYREPAM AVQEPVTVKE EPEPEVRMVN
     GKPKKIRKPR TIYSSYQLAA LQRRFQKAQY LALPERAELA AQLGLTQTQV KIWFQNRRSK
     FKKLYKNGEV PGMEHSPDNS DSMACNSPAS PTVWDNNTPS RAHDPQAQPL PHNSSPSYLE
     DYNPWYHHPQ NLSGPHLQPP GTMHHTPPGT GAVY