ID   DLX4B_DANRE             Reviewed;         254 AA.
AC   Q98878; B2GRG6; F1R2R2; Q568U7;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   07-SEP-2016, sequence version 2.
DT   03-AUG-2022, entry version 136.
DE   RecName: Full=Homeobox protein Dlx4b;
DE   AltName: Full=DLX-7;
DE   AltName: Full=Distal-less homeobox protein 4b;
GN   Name=dlx4b; Synonyms=dlx7; ORFNames=zgc:109858;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Larva;
RX   PubMed=8855272; DOI=10.1073/pnas.93.20.10858;
RA   Stock D.W., Ellies D.L., Zhao Z., Ekker M., Ruddle F.H., Weiss K.M.;
RT   "The evolution of the vertebrate Dlx gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 93:10858-10863(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Olfactory epithelium;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   DISRUPTION PHENOTYPE, AND FUNCTION.
RX   PubMed=25954033; DOI=10.1093/hmg/ddv167;
RA   Wu D., Mandal S., Choi A., Anderson A., Prochazkova M., Perry H.,
RA   Gil-Da-Silva-Lopes V.L., Lao R., Wan E., Tang P.L., Kwok P.Y., Klein O.,
RA   Zhuan B., Slavotinek A.M.;
RT   "DLX4 is associated with orofacial clefting and abnormal jaw development.";
RL   Hum. Mol. Genet. 24:4340-4352(2015).
CC   -!- FUNCTION: During larvae development, may be important for neurocranium
CC       morphogenesis. {ECO:0000269|PubMed:25954033}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q92988}.
CC   -!- DISRUPTION PHENOTYPE: Morpholino knockdown of the protein causes
CC       reduced cranial outgrowth and defects of the cartilaginous elements of
CC       the jaw. {ECO:0000269|PubMed:25954033}.
CC   -!- SIMILARITY: Belongs to the distal-less homeobox family. {ECO:0000305}.
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DR   EMBL; U67845; AAC60028.1; -; mRNA.
DR   EMBL; CU468219; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC092714; AAH92714.1; -; mRNA.
DR   EMBL; BC165120; AAI65120.1; -; mRNA.
DR   RefSeq; NP_571393.1; NM_131318.1.
DR   AlphaFoldDB; Q98878; -.
DR   SMR; Q98878; -.
DR   STRING; 7955.ENSDARP00000096665; -.
DR   PaxDb; Q98878; -.
DR   Ensembl; ENSDART00000105887; ENSDARP00000096665; ENSDARG00000071560.
DR   GeneID; 30581; -.
DR   KEGG; dre:30581; -.
DR   CTD; 30581; -.
DR   ZFIN; ZDB-GENE-990415-50; dlx4b.
DR   eggNOG; KOG0850; Eukaryota.
DR   GeneTree; ENSGT00940000165079; -.
DR   InParanoid; Q98878; -.
DR   OMA; MGFMPDS; -.
DR   OrthoDB; 1416398at2759; -.
DR   PhylomeDB; Q98878; -.
DR   TreeFam; TF315720; -.
DR   PRO; PR:Q98878; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 12.
DR   Bgee; ENSDARG00000071560; Expressed in cranial placode and 44 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0042667; P:auditory receptor cell fate specification; IGI:ZFIN.
DR   GO; GO:0043010; P:camera-type eye development; IGI:ZFIN.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IMP:ZFIN.
DR   GO; GO:0035270; P:endocrine system development; IGI:ZFIN.
DR   GO; GO:0060119; P:inner ear receptor cell development; IGI:ZFIN.
DR   GO; GO:0070306; P:lens fiber cell differentiation; IGI:ZFIN.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0048666; P:neuron development; IGI:ZFIN.
DR   GO; GO:0030910; P:olfactory placode formation; IGI:ZFIN.
DR   GO; GO:0043049; P:otic placode formation; IGI:ZFIN.
DR   GO; GO:0030916; P:otic vesicle formation; IGI:ZFIN.
DR   GO; GO:0071600; P:otic vesicle morphogenesis; IGI:ZFIN.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0021559; P:trigeminal nerve development; IGI:ZFIN.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..254
FT                   /note="Homeobox protein Dlx4b"
FT                   /id="PRO_0000049051"
FT   DNA_BIND        129..188
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   CONFLICT        106
FT                   /note="N -> D (in Ref. 1; AAC60028 and 3; AAH92714/
FT                   AAI65120)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   254 AA;  28183 MW;  D9BFFB1F02C3534F CRC64;
     MMSMSFMSDT LNSSDPSKSA FLEFGHGLAS NQQHLSGFAH NIYPVHGLHS GGHLQHDAPY
     PSSAPHYSRP LGYAYPGPVS AAAPGAYMPY QPNNHSGALA HTRAENTNHE KPAVIENGEI
     RLNGKGKKIR KPRTIYSSVQ LQALHQRFQQ TQYLALPERA DLAAKLGLTQ TQVKIWFQNK
     RSKYKKIMKH GSSGPEGELL HTSSSSPCSP GLSQLWEVSM ANKVPPMHPS SYMNNYGHWY
     PPHHQDPVPR PQMM