ID   DLX4_ELECQ              Reviewed;         131 AA.
AC   P87394;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Homeobox protein DLX-4;
DE   Flags: Fragment;
GN   Name=DLX4;
OS   Eleutherodactylus coqui (Puerto Rican coqui).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Eleutherodactylidae;
OC   Eleutherodactylinae; Eleutherodactylus; Eleutherodactylus.
OX   NCBI_TaxID=57060;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8873761; DOI=10.1006/dbio.1996.0248;
RA   Fang H., Elinson R.P.;
RT   "Patterns of distal-less gene expression and inductive interactions in the
RT   head of the direct developing frog Eleutherodactylus coqui.";
RL   Dev. Biol. 179:160-172(1996).
CC   -!- FUNCTION: During development, may be important for neurocranium
CC       morphogenesis. {ECO:0000250|UniProtKB:B2GRG6}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q92988}.
CC   -!- DEVELOPMENTAL STAGE: At stage 14, detected in cells of the anterior and
CC       anterior-lateral rim of the neural plate. After neural tube closure,
CC       detected externally in cells in the dorsal-midline of the closed neural
CC       tube. At TS3 expressed in the region corresponding to olfactory
CC       placode, at TS5 detected in all branchial arches and at stage TS6
CC       expressed in the putative apical ectodermal ridge of the limb buds.
CC   -!- SIMILARITY: Belongs to the distal-less homeobox family. {ECO:0000305}.
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DR   EMBL; S83212; AAD14432.1; -; mRNA.
DR   AlphaFoldDB; P87394; -.
DR   SMR; P87394; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR022135; Distal-less_N.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF12413; DLL_N; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus.
FT   CHAIN           <1..>131
FT                   /note="Homeobox protein DLX-4"
FT                   /id="PRO_0000049042"
FT   DNA_BIND        82..>131
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          48..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT   NON_TER         131
SQ   SEQUENCE   131 AA;  14774 MW;  A2BA8E03D5519398 CRC64;
     GLPHSASYGK ALNAYQYQYH GMSGSAGSYA AKAYSEYSYG SPYHPHHQYS GAYNRVQPPS
     TQPEKEVAEP EVRMVNGKPK KIRKPRTIYS SFQVAALQRR FQKTQYLALP ERAELAASLG
     LTQTQVKIWF Q