DLX4_MOUSE
ID DLX4_MOUSE Reviewed; 240 AA.
AC P70436; Q3UM51; Q8R4I3;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 2.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=Homeobox protein DLX-4;
DE AltName: Full=Homeobox protein DLX-7;
GN Name=Dlx4; Synonyms=Dlx7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Swiss Webster; TISSUE=Mandible;
RX PubMed=8975708; DOI=10.1006/geno.1996.0634;
RA Nakamura S., Stock D.W., Wydner K.L., Bollekens J.A., Takeshita K.,
RA Nagai B.M., Chiba S., Kitamura T., Freeland T.M., Zhao Z., Minowada J.,
RA Lawrence J.B., Weiss K.M., Ruddle F.H.;
RT "Genomic analysis of a new mammalian distal-less gene: Dlx7.";
RL Genomics 38:314-324(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/Ola;
RX PubMed=11792834; DOI=10.1073/pnas.012584999;
RA Sumiyama K., Irvine S.Q., Stock D.W., Weiss K.M., Kawasaki K., Shimizu N.,
RA Shashikant C.S., Miller W., Ruddle F.H.;
RT "Genomic structure and functional control of the Dlx3-7 bigene cluster.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:780-785(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary gland;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP DEVELOPMENTAL STAGE.
RX PubMed=25954033; DOI=10.1093/hmg/ddv167;
RA Wu D., Mandal S., Choi A., Anderson A., Prochazkova M., Perry H.,
RA Gil-Da-Silva-Lopes V.L., Lao R., Wan E., Tang P.L., Kwok P.Y., Klein O.,
RA Zhuan B., Slavotinek A.M.;
RT "DLX4 is associated with orofacial clefting and abnormal jaw development.";
RL Hum. Mol. Genet. 24:4340-4352(2015).
CC -!- FUNCTION: May play a role in determining the production of hemoglobin
CC S. May act as a repressor. During embryonic development, plays a role
CC in palatogenesis. {ECO:0000250|UniProtKB:Q92988}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q92988}.
CC -!- TISSUE SPECIFICITY: Branchial arches, molar and incisor teeth and
CC limbs.
CC -!- DEVELOPMENTAL STAGE: Expressed in the mesenchyme of the anterior palate
CC at 12.5 dpc, prior to the time of palate closure. Expression levels
CC decrease at later time periods after palate closure.
CC {ECO:0000269|PubMed:25954033}.
CC -!- SIMILARITY: Belongs to the distal-less homeobox family. {ECO:0000305}.
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DR EMBL; U73329; AAC52995.1; -; mRNA.
DR EMBL; AF452637; AAL99501.1; -; Genomic_DNA.
DR EMBL; AK145123; BAE26247.1; -; mRNA.
DR EMBL; AL645850; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC106967; AAI06968.1; -; mRNA.
DR CCDS; CCDS25273.1; -.
DR RefSeq; NP_031893.3; NM_007867.4.
DR AlphaFoldDB; P70436; -.
DR SMR; P70436; -.
DR BioGRID; 199237; 2.
DR IntAct; P70436; 3.
DR STRING; 10090.ENSMUSP00000021241; -.
DR PaxDb; P70436; -.
DR PeptideAtlas; P70436; -.
DR PRIDE; P70436; -.
DR Antibodypedia; 17993; 435 antibodies from 32 providers.
DR DNASU; 13394; -.
DR Ensembl; ENSMUST00000021241; ENSMUSP00000021241; ENSMUSG00000020871.
DR GeneID; 13394; -.
DR KEGG; mmu:13394; -.
DR UCSC; uc007kzz.2; mouse.
DR CTD; 1748; -.
DR MGI; MGI:94904; Dlx4.
DR VEuPathDB; HostDB:ENSMUSG00000020871; -.
DR eggNOG; KOG0850; Eukaryota.
DR GeneTree; ENSGT00940000162259; -.
DR HOGENOM; CLU_074733_2_1_1; -.
DR InParanoid; P70436; -.
DR OMA; GNNFGAW; -.
DR OrthoDB; 1416398at2759; -.
DR PhylomeDB; P70436; -.
DR TreeFam; TF315720; -.
DR BioGRID-ORCS; 13394; 0 hits in 72 CRISPR screens.
DR PRO; PR:P70436; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; P70436; protein.
DR Bgee; ENSMUSG00000020871; Expressed in hair follicle and 37 other tissues.
DR Genevisible; P70436; MM.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:MGI.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISO:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR000047; HTH_motif.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..240
FT /note="Homeobox protein DLX-4"
FT /id="PRO_0000049029"
FT DNA_BIND 116..175
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 44..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 175..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 132
FT /note="N -> D (in Ref. 1; AAC52995)"
FT /evidence="ECO:0000305"
FT CONFLICT 194
FT /note="S -> F (in Ref. 3; BAE26247)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 240 AA; 26579 MW; ECDC4D943E22364C CRC64;
MTSLPCPLPD RGASNVVFPD LAPALSVVAA YPLGLSPGTA ASPDLSYSQS YGHPRSYSHP
GPATPGDSYL PRQQQLVAPS QPFHRPAEHP QELEAESEKL ALSLVPSQQQ SLTRKLRKPR
TIYSSLQLQH LNQRFQHTQY LALPERAQLA AQLGLTQTQV KIWFQNKRSK YKKLLKQSSG
EPEEDFSGRP PSLSPHSPAL PFIWGLPKAD TLPSSGYDNS HFGAWYQHRS PDVLALPQMM
