ID   DLX5A_DANRE             Reviewed;         283 AA.
AC   P50576;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Homeobox protein Dlx5a;
DE   AltName: Full=DLX-4;
DE   AltName: Full=Distal-less homeobox protein 5a;
GN   Name=dlx5a; Synonyms=dlx4;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7911517; DOI=10.1523/jneurosci.14-06-03475.1994;
RA   Akimenko M.-A., Ekker M., Wegner J., Lin W., Westerfield M.;
RT   "Combinatorial expression of three zebrafish genes related to distal-less:
RT   part of a homeobox gene code for the head.";
RL   J. Neurosci. 14:3475-3486(1994).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- DEVELOPMENTAL STAGE: Not expressed during gastrulation, and shortly
CC       after gastrulation found in the cells of the ventral fore-brain
CC       rudiment, presumptive precursor cells of the olfactory placodes,
CC       overlapping subsets of cells in the auditory vesicle, cells of the
CC       median fin fold, and cells of the visceral arches and their primordia.
CC   -!- SIMILARITY: Belongs to the distal-less homeobox family. {ECO:0000305}.
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DR   EMBL; U03876; AAA19827.1; -; mRNA.
DR   PIR; I50112; I50112.
DR   AlphaFoldDB; P50576; -.
DR   SMR; P50576; -.
DR   STRING; 7955.ENSDARP00000100492; -.
DR   ZFIN; ZDB-GENE-990415-49; dlx5a.
DR   eggNOG; KOG0850; Eukaryota.
DR   InParanoid; P50576; -.
DR   PhylomeDB; P50576; -.
DR   PRO; PR:P50576; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0048646; P:anatomical structure formation involved in morphogenesis; IBA:GO_Central.
DR   GO; GO:0051216; P:cartilage development; IGI:ZFIN.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IGI:ZFIN.
DR   GO; GO:0033334; P:fin morphogenesis; IMP:ZFIN.
DR   GO; GO:0035141; P:medial fin morphogenesis; IGI:ZFIN.
DR   GO; GO:0001841; P:neural tube formation; IMP:ZFIN.
DR   GO; GO:0021628; P:olfactory nerve formation; IMP:ZFIN.
DR   GO; GO:0071699; P:olfactory placode morphogenesis; IMP:ZFIN.
DR   GO; GO:0033339; P:pectoral fin development; IGI:ZFIN.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0009612; P:response to mechanical stimulus; IDA:ZFIN.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR022135; Distal-less_N.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF12413; DLL_N; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..283
FT                   /note="Homeobox protein Dlx5a"
FT                   /id="PRO_0000049052"
FT   DNA_BIND        137..196
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          15..47
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          198..237
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        17..46
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        203..237
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   283 AA;  31562 MW;  E8728F1975FB47EB CRC64;
     MTGVFDRRIP SIKPADFQNP FQLSTMHHPS QESPTLPEST ATDSGYYSPA GGVHHGYCSP
     NSGTYGKPLN AYQYQYHGVN GSSGNYSAKS YPDYGSYSTA YHQYAGTYNR VQSQPSPQEK
     ETAEPEVRMV NGKPKKVRKP RTIYSSFQLA ALQRRFQNTQ YLALPERAEL AASLGLTQTQ
     VKIWFQNKRS KLKKIMKNGE LPPEHSPSSS DPMACNSPQS PAVWDSQGPQ RPHHQPQNIN
     TAASTFLEMR ELFVVFLYRG DEFFTLQAPG TLHSLALGSG TLY