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DLX5_CHICK
ID   DLX5_CHICK              Reviewed;         286 AA.
AC   P50577; Q549L3;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 139.
DE   RecName: Full=Homeobox protein DLX-5;
DE            Short=cDlx;
GN   Name=DLX5; Synonyms=DLX-5;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=White leghorn;
RX   PubMed=8541214; DOI=10.1016/0925-4773(95)98113-o;
RA   Ferrari D., Sumoy L., Gannon J., Sun H., Brown A.M., Upholt W.B.,
RA   Kosher R.A.;
RT   "The expression pattern of the Distal-less homeobox-containing gene Dlx-5
RT   in the developing chick limb bud suggests its involvement in apical
RT   ectodermal ridge activity, pattern formation, and cartilage
RT   differentiation.";
RL   Mech. Dev. 52:257-264(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=White leghorn;
RX   PubMed=10894982; DOI=10.1159/000017441;
RA   Borghjid S., Siddiqui M.A.Q.;
RT   "Chick homeobox gene cDlx expression demarcates the forebrain anlage,
RT   indicating the onset of forebrain regional specification at gastrulation.";
RL   Dev. Neurosci. 22:183-196(2000).
CC   -!- FUNCTION: Transcriptional factor involved in bone development. Could be
CC       involved in apical ectodermal ridge activity, pattern formation, and
CC       cartilage differentiation. Binds to DNA.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the distal-less homeobox family. {ECO:0000305}.
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DR   EMBL; U25274; AAA96145.1; -; mRNA.
DR   EMBL; AF096161; AAF00085.1; -; mRNA.
DR   RefSeq; NP_989490.1; NM_204159.1.
DR   AlphaFoldDB; P50577; -.
DR   BMRB; P50577; -.
DR   SMR; P50577; -.
DR   STRING; 9031.ENSGALP00000014846; -.
DR   PaxDb; P50577; -.
DR   Ensembl; ENSGALT00000014862; ENSGALP00000014846; ENSGALG00000009129.
DR   GeneID; 373969; -.
DR   KEGG; gga:373969; -.
DR   CTD; 1749; -.
DR   VEuPathDB; HostDB:geneid_373969; -.
DR   eggNOG; KOG0850; Eukaryota.
DR   GeneTree; ENSGT00940000159188; -.
DR   HOGENOM; CLU_074733_0_0_1; -.
DR   InParanoid; P50577; -.
DR   OMA; THGYCSP; -.
DR   OrthoDB; 1416398at2759; -.
DR   PhylomeDB; P50577; -.
DR   TreeFam; TF350606; -.
DR   PRO; PR:P50577; -.
DR   Proteomes; UP000000539; Chromosome 2.
DR   Bgee; ENSGALG00000009129; Expressed in brain.
DR   GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0071837; F:HMG box domain binding; IEA:Ensembl.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0048646; P:anatomical structure formation involved in morphogenesis; IBA:GO_Central.
DR   GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0008283; P:cell population proliferation; IEA:Ensembl.
DR   GO; GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl.
DR   GO; GO:0001958; P:endochondral ossification; IEA:Ensembl.
DR   GO; GO:0030855; P:epithelial cell differentiation; IEA:Ensembl.
DR   GO; GO:0060325; P:face morphogenesis; IEA:Ensembl.
DR   GO; GO:0042472; P:inner ear morphogenesis; IEA:Ensembl.
DR   GO; GO:0097376; P:interneuron axon guidance; IEA:Ensembl.
DR   GO; GO:0021889; P:olfactory bulb interneuron differentiation; IEA:Ensembl.
DR   GO; GO:0060166; P:olfactory pit development; IEA:Ensembl.
DR   GO; GO:0001649; P:osteoblast differentiation; IEA:Ensembl.
DR   GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR   GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:1901522; P:positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0060021; P:roof of mouth development; IEA:Ensembl.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR022135; Distal-less_N.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF12413; DLL_N; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Osteogenesis;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..286
FT                   /note="Homeobox protein DLX-5"
FT                   /id="PRO_0000049030"
FT   DNA_BIND        136..195
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..52
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          197..286
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        16..48
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        202..226
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   286 AA;  30949 MW;  5A694A07207573DF CRC64;
     MTAVFDRRVP GIRSSDFQPP FQSAAAMHHP SQESPTLPES SATDSDYYSP TGAAPHGYCS
     PTSASYGKAL NPYQYQYGMN GSAGTYPAKA YADYGYGSPY HQYGGAYGRG QSSAGQPEKE
     VAEPEVRMVN GKPKKVRKPR TIYSSFQLAA LQRRFQKTQY LALPERAELA ASLGLTQTQV
     KIWFQNKRSK IKKIMKNGEM PPEHSPSSSD PMACNSPQSP AVWEPQGSSR SLGHHGHGHP
     PAANPSPGSY LESPSAWYPA ASPLGSHLQP HGSLQHPLAL PSGTIY
 
 
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