DLX6A_DANRE
ID DLX6A_DANRE Reviewed; 247 AA.
AC Q98877;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Homeobox protein Dlx6a;
DE AltName: Full=Distal-less homeobox protein 6a;
DE Short=DLX-6;
GN Name=dlx6a; Synonyms=dlx6;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Larva;
RX PubMed=8855272; DOI=10.1073/pnas.93.20.10858;
RA Stock D.W., Ellies D.L., Zhao Z., Ekker M., Ruddle F.H., Weiss K.M.;
RT "The evolution of the vertebrate Dlx gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:10858-10863(1996).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the distal-less homeobox family. {ECO:0000305}.
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DR EMBL; U67844; AAC60027.1; -; mRNA.
DR RefSeq; NP_571398.1; NM_131323.1.
DR AlphaFoldDB; Q98877; -.
DR SMR; Q98877; -.
DR STRING; 7955.ENSDARP00000093553; -.
DR PaxDb; Q98877; -.
DR Ensembl; ENSDART00000102778; ENSDARP00000093553; ENSDARG00000042291.
DR GeneID; 30586; -.
DR KEGG; dre:30586; -.
DR CTD; 30586; -.
DR ZFIN; ZDB-GENE-980526-448; dlx6a.
DR eggNOG; KOG0850; Eukaryota.
DR GeneTree; ENSGT00940000157683; -.
DR HOGENOM; CLU_074733_2_0_1; -.
DR InParanoid; Q98877; -.
DR OMA; MAGGHYP; -.
DR OrthoDB; 1416398at2759; -.
DR PhylomeDB; Q98877; -.
DR TreeFam; TF315720; -.
DR PRO; PR:Q98877; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 19.
DR Bgee; ENSDARG00000042291; Expressed in skeleton of lower jaw and 41 other tissues.
DR ExpressionAtlas; Q98877; baseline.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0035141; P:medial fin morphogenesis; IGI:ZFIN.
DR GO; GO:0001841; P:neural tube formation; IMP:ZFIN.
DR GO; GO:0033339; P:pectoral fin development; IGI:ZFIN.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR000047; HTH_motif.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..247
FT /note="Homeobox protein Dlx6a"
FT /id="PRO_0000049053"
FT DNA_BIND 125..184
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 22..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 247 AA; 27624 MW; FF2AB129C637A450 CRC64;
MMTMTTMADG LEAQDSSKSA FMEFGQQSHS QQSSPSMAAS HYPLHCLHSG SHHHHQHDSS
PYSGSNSYNR SLPYSYVSHP HHSPYLPSYH SNASGTQTRL DATEQQKTTV IENGEIRFNG
KGKKIRKPRT IYSSLQLQAL NHRFQQTQYL ALPERAELAA SLGLTQTQVK IWFQNKRSKF
KKLLKQGGNP HETDTLPGSI ALSPRSPAIP PIWDVSASSK GVNMSANSYM PGYSHWYSSP
HQDAMQR
