DLX6_MOUSE
ID DLX6_MOUSE Reviewed; 175 AA.
AC P70397; A0AUM1; A5HKN2;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 3.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Homeobox protein DLX-6;
GN Name=Dlx6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Femur;
RX PubMed=18280462; DOI=10.1016/j.ydbio.2008.01.001;
RA Li H., Marijanovic I., Kronenberg M.S., Erceg I., Stover M.L., Velonis D.,
RA Mina M., Heinrich J.G., Harris S.E., Upholt W.B., Kalajzic I.,
RA Lichtler A.C.;
RT "Expression and function of Dlx genes in the osteoblast lineage.";
RL Dev. Biol. 316:458-470(2008).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Branchial arch region;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-175 (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 18-175 (ISOFORM 1).
RC TISSUE=Branchial arch region;
RX PubMed=9415433;
RX DOI=10.1002/(sici)1097-0177(199712)210:4<498::aid-aja12>3.0.co;2-3;
RA Liu J.K., Ghattas I., Liu S., Chen S., Rubenstein J.L.R.;
RT "Dlx genes encode DNA-binding proteins that are expressed in an overlapping
RT and sequential pattern during basal ganglia differentiation.";
RL Dev. Dyn. 210:498-512(1997).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 53-175 (ISOFORM 1).
RC STRAIN=Swiss Webster; TISSUE=Embryo;
RX PubMed=8855272; DOI=10.1073/pnas.93.20.10858;
RA Stock D.W., Ellies D.L., Zhao Z., Ekker M., Ruddle F.H., Weiss K.M.;
RT "The evolution of the vertebrate Dlx gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:10858-10863(1996).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P70397-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P70397-2; Sequence=VSP_040733;
CC -!- SIMILARITY: Belongs to the distal-less homeobox family. {ECO:0000305}.
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DR EMBL; EF535989; ABQ10645.1; -; mRNA.
DR EMBL; AC122240; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC114342; AAI14343.1; -; mRNA.
DR EMBL; AF022078; AAB94583.1; -; mRNA.
DR EMBL; U67841; AAC52844.1; -; mRNA.
DR CCDS; CCDS51719.1; -. [P70397-2]
DR RefSeq; NP_034187.1; NM_010057.2. [P70397-2]
DR AlphaFoldDB; P70397; -.
DR SMR; P70397; -.
DR STRING; 10090.ENSMUSP00000124204; -.
DR iPTMnet; P70397; -.
DR PhosphoSitePlus; P70397; -.
DR PaxDb; P70397; -.
DR PeptideAtlas; P70397; -.
DR PRIDE; P70397; -.
DR ProteomicsDB; 279556; -. [P70397-1]
DR ProteomicsDB; 279557; -. [P70397-2]
DR Antibodypedia; 30192; 187 antibodies from 24 providers.
DR DNASU; 13396; -.
DR Ensembl; ENSMUST00000160937; ENSMUSP00000124204; ENSMUSG00000029754. [P70397-2]
DR Ensembl; ENSMUST00000171311; ENSMUSP00000128585; ENSMUSG00000029754. [P70397-2]
DR GeneID; 13396; -.
DR KEGG; mmu:13396; -.
DR UCSC; uc009aww.1; mouse. [P70397-2]
DR CTD; 1750; -.
DR MGI; MGI:101927; Dlx6.
DR VEuPathDB; HostDB:ENSMUSG00000029754; -.
DR eggNOG; KOG0850; Eukaryota.
DR GeneTree; ENSGT00940000157683; -.
DR HOGENOM; CLU_074733_2_0_1; -.
DR InParanoid; P70397; -.
DR OMA; MAGGHYP; -.
DR OrthoDB; 1416398at2759; -.
DR PhylomeDB; P70397; -.
DR TreeFam; TF315720; -.
DR BioGRID-ORCS; 13396; 0 hits in 74 CRISPR screens.
DR PRO; PR:P70397; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; P70397; protein.
DR Bgee; ENSMUSG00000029754; Expressed in embryonic brain and 83 other tissues.
DR ExpressionAtlas; P70397; baseline and differential.
DR Genevisible; P70397; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0048646; P:anatomical structure formation involved in morphogenesis; IGI:MGI.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0030326; P:embryonic limb morphogenesis; IGI:MGI.
DR GO; GO:0030855; P:epithelial cell differentiation; IGI:MGI.
DR GO; GO:0060322; P:head development; IGI:MGI.
DR GO; GO:0042472; P:inner ear morphogenesis; IGI:MGI.
DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IGI:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0060021; P:roof of mouth development; IGI:MGI.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR000047; HTH_motif.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Developmental protein; DNA-binding; Homeobox;
KW Nucleus; Reference proteome.
FT CHAIN 1..175
FT /note="Homeobox protein DLX-6"
FT /id="PRO_0000049035"
FT DNA_BIND 49..108
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 109..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1
FT /note="M -> MMTMTTMADGLEGQDSSKSAFMEFGQQQQQQQQQQQQQQQQQQQQQQ
FT PPPPPPPPPPQPHSQQTSPAMAGAHYPLHCLHSAAAAAAAAGSHHHHHQHHHHGSPYAS
FT SGGNSYNHRSLAAYPYM (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:18280462"
FT /id="VSP_040733"
SQ SEQUENCE 175 AA; 19677 MW; 55542638D7E0CA42 CRC64;
MSHSQHSPYL QSYHNSSAAA QTRGDDTDQQ KTTVIENGEI RFNGKGKKIR KPRTIYSSLQ
LQALNHRFQQ TQYLALPERA ELAASLGLTQ TQVKIWFQNK RSKFKKLLKQ GSNPHESDPL
PGSAALSPRS PALPPVWDVS ASAKGVSMPP NSYMPGYSHW YSSPHQDTMQ RPQMM
