DMAC1_MOUSE
ID DMAC1_MOUSE Reviewed; 111 AA.
AC Q9CQ00;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Distal membrane-arm assembly complex protein 1 {ECO:0000250|UniProtKB:Q96GE9};
DE AltName: Full=Transmembrane protein 261 {ECO:0000305};
GN Name=Dmac1 {ECO:0000250|UniProtKB:Q96GE9};
GN Synonyms=Tmem261 {ECO:0000312|MGI:MGI:1914178};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Heart, and Liver;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Required for the assembly of the mitochondrial
CC NADH:ubiquinone oxidoreductase complex (complex I). Involved in the
CC assembly of the distal region of complex I.
CC {ECO:0000250|UniProtKB:Q96GE9}.
CC -!- SUBUNIT: Interacts with incompletely assembled mitochondrial
CC NADH:ubiquinone oxidoreductase complex (complex I).
CC {ECO:0000250|UniProtKB:Q96GE9}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q96GE9}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q96GE9}.
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DR EMBL; AK003640; BAB22906.1; -; mRNA.
DR EMBL; AK013937; BAB29069.1; -; mRNA.
DR EMBL; AL773510; CAD83065.1; -; Genomic_DNA.
DR EMBL; BC022621; AAH22621.1; -; mRNA.
DR CCDS; CCDS18288.1; -.
DR RefSeq; NP_080125.1; NM_025849.3.
DR AlphaFoldDB; Q9CQ00; -.
DR IntAct; Q9CQ00; 1.
DR STRING; 10090.ENSMUSP00000030103; -.
DR iPTMnet; Q9CQ00; -.
DR PhosphoSitePlus; Q9CQ00; -.
DR EPD; Q9CQ00; -.
DR jPOST; Q9CQ00; -.
DR MaxQB; Q9CQ00; -.
DR PaxDb; Q9CQ00; -.
DR PeptideAtlas; Q9CQ00; -.
DR PRIDE; Q9CQ00; -.
DR ProteomicsDB; 279546; -.
DR Antibodypedia; 3009; 19 antibodies from 10 providers.
DR DNASU; 66928; -.
DR Ensembl; ENSMUST00000030103; ENSMUSP00000030103; ENSMUSG00000028398.
DR GeneID; 66928; -.
DR KEGG; mmu:66928; -.
DR UCSC; uc008tjk.1; mouse.
DR CTD; 90871; -.
DR MGI; MGI:1914178; Dmac1.
DR VEuPathDB; HostDB:ENSMUSG00000028398; -.
DR eggNOG; ENOG502S9M0; Eukaryota.
DR GeneTree; ENSGT00390000003343; -.
DR HOGENOM; CLU_171933_0_0_1; -.
DR InParanoid; Q9CQ00; -.
DR OMA; WSCRILS; -.
DR OrthoDB; 1574039at2759; -.
DR PhylomeDB; Q9CQ00; -.
DR TreeFam; TF330733; -.
DR BioGRID-ORCS; 66928; 16 hits in 73 CRISPR screens.
DR ChiTaRS; Dmac1; mouse.
DR PRO; PR:Q9CQ00; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q9CQ00; protein.
DR Bgee; ENSMUSG00000028398; Expressed in dorsal pancreas and 257 other tissues.
DR Genevisible; Q9CQ00; MM.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISO:MGI.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR028036; DUF4536.
DR Pfam; PF15055; DUF4536; 1.
PE 1: Evidence at protein level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..111
FT /note="Distal membrane-arm assembly complex protein 1"
FT /id="PRO_0000089730"
FT TRANSMEM 51..68
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 111 AA; 11344 MW; E0C6948341956D84 CRC64;
MGSSFSGSTE FSAPAPPTVS TAVPANPPAK SAVPASPARD PELKTCWSCR VLSGSTLFGA
GTYVYLVARR PLKQGIPPGP GTVLQMVIGI SIACWGVVVL VDPKGKSHPV I
