DMAC2_MOUSE
ID DMAC2_MOUSE Reviewed; 258 AA.
AC Q9D7K5;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Distal membrane-arm assembly complex protein 2 {ECO:0000250|UniProtKB:Q9NW81};
DE AltName: Full=ATP synthase subunit s-like protein {ECO:0000305};
GN Name=Dmac2; Synonyms=Atp5sl {ECO:0000312|MGI:MGI:1913599};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP SUBCELLULAR LOCATION.
RX PubMed=18614015; DOI=10.1016/j.cell.2008.06.016;
RA Pagliarini D.J., Calvo S.E., Chang B., Sheth S.A., Vafai S.B., Ong S.E.,
RA Walford G.A., Sugiana C., Boneh A., Chen W.K., Hill D.E., Vidal M.,
RA Evans J.G., Thorburn D.R., Carr S.A., Mootha V.K.;
RT "A mitochondrial protein compendium elucidates complex I disease biology.";
RL Cell 134:112-123(2008).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Heart, Kidney, Liver, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Required for the assembly of the mitochondrial
CC NADH:ubiquinone oxidoreductase complex (complex I). Involved in the
CC assembly of the distal region of complex I.
CC {ECO:0000250|UniProtKB:Q9NW81}.
CC -!- SUBUNIT: Interacts with incompletely assembled mitochondrial
CC NADH:ubiquinone oxidoreductase complex (complex I).
CC {ECO:0000250|UniProtKB:Q9NW81}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:18614015}.
CC -!- SIMILARITY: Belongs to the ATP synthase subunit s family.
CC {ECO:0000305}.
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DR EMBL; AK009150; BAB26107.1; -; mRNA.
DR CCDS; CCDS71917.1; -.
DR RefSeq; NP_001277416.1; NM_001290487.1.
DR AlphaFoldDB; Q9D7K5; -.
DR SMR; Q9D7K5; -.
DR STRING; 10090.ENSMUSP00000083115; -.
DR PhosphoSitePlus; Q9D7K5; -.
DR EPD; Q9D7K5; -.
DR MaxQB; Q9D7K5; -.
DR PaxDb; Q9D7K5; -.
DR PRIDE; Q9D7K5; -.
DR ProteomicsDB; 279547; -.
DR Antibodypedia; 62280; 32 antibodies from 10 providers.
DR DNASU; 66349; -.
DR Ensembl; ENSMUST00000077338; ENSMUSP00000076563; ENSMUSG00000057229.
DR GeneID; 66349; -.
DR KEGG; mmu:66349; -.
DR UCSC; uc009fte.2; mouse.
DR CTD; 55101; -.
DR MGI; MGI:1913599; Dmac2.
DR VEuPathDB; HostDB:ENSMUSG00000057229; -.
DR eggNOG; KOG3864; Eukaryota.
DR GeneTree; ENSGT00940000160500; -.
DR HOGENOM; CLU_072474_0_0_1; -.
DR InParanoid; Q9D7K5; -.
DR OMA; EEADMSY; -.
DR OrthoDB; 1458966at2759; -.
DR PhylomeDB; Q9D7K5; -.
DR BioGRID-ORCS; 66349; 17 hits in 71 CRISPR screens.
DR PRO; PR:Q9D7K5; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q9D7K5; protein.
DR Bgee; ENSMUSG00000057229; Expressed in retinal neural layer and 207 other tissues.
DR ExpressionAtlas; Q9D7K5; baseline and differential.
DR Genevisible; Q9D7K5; MM.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISO:MGI.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR032675; LRR_dom_sf.
PE 1: Evidence at protein level;
KW Mitochondrion; Reference proteome.
FT CHAIN 1..258
FT /note="Distal membrane-arm assembly complex protein 2"
FT /id="PRO_0000318697"
SQ SEQUENCE 258 AA; 29179 MW; C43E4A5C986CE7F9 CRC64;
MAAPRAVLHL GAREWNGRAR RIHGMSELVT PDSSREKKRT LLQFLSDHFQ DIQTLREYLL
QKQISKVNRE NRSFTNIQEK YGPYVAGAVF ILKQGGAVKF QDKEEWIRPN NRSHFLAEIQ
KFQNVPVEAV DASGCAINYQ GLSNLLPLKE LRSLSLQRCP NLDDWCLSRL YLLAGSLQEL
SLAGCPRISE RGLACLHHLQ NLRRLDISDL PAVSHPGLTQ ILVEEMLPHC EVLGADWAQN
LKLEPDKQPP DTSTPLSS
