ID   DMA_SQUAC               Reviewed;         245 AA.
AC   P36963;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Proteolipid protein DM alpha;
OS   Squalus acanthias (Spiny dogfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Squalomorphii; Squaliformes; Squalidae; Squalus.
OX   NCBI_TaxID=7797;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=8398138; DOI=10.1016/0896-6273(93)90148-k;
RA   Kitagawa K., Sinoway M.P., Yang C., Gould R.M., Colman D.R.;
RT   "A proteolipid protein gene family: expression in sharks and rays and
RT   possible evolution from an ancestral gene encoding a pore-forming
RT   polypeptide.";
RL   Neuron 11:433-448(1993).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in white matter in myelinating
CC       shark brain.
CC   -!- SIMILARITY: Belongs to the myelin proteolipid protein family.
CC       {ECO:0000305}.
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DR   EMBL; U02973; AAC59639.1; -; mRNA.
DR   PIR; I51323; I51323.
DR   AlphaFoldDB; P36963; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR001614; Myelin_PLP.
DR   InterPro; IPR018237; Myelin_PLP_CS.
DR   PANTHER; PTHR11683; PTHR11683; 1.
DR   Pfam; PF01275; Myelin_PLP; 1.
DR   PRINTS; PR00214; MYELINPLP.
DR   SMART; SM00002; PLP; 1.
DR   PROSITE; PS00575; MYELIN_PLP_1; 1.
DR   PROSITE; PS01004; MYELIN_PLP_2; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..245
FT                   /note="Proteolipid protein DM alpha"
FT                   /id="PRO_0000159015"
FT   TRANSMEM        19..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        204..220
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   245 AA;  26910 MW;  521B0A11076B16C5 CRC64;
     MGCSECCVRC LGGVPYASLI ATILCFVGVA LFCGCGHEAL TGTEKLIELY FSNDFMDYAL
     LVNVIQVFQY IIYGTASFSF LYGVLLLAEG FYTTSAVKAL FGEFRTTVCG RCVSATFIFL
     TYALGVTWMG VFAFSALPVY IYYTMWSTCQ MVKYVTENGT GFDDICVDAR QYGILPWNAS
     PGKICGLSLA AVCNTSEFEL TYHLFIATFA GAAATVIALL TYMMSSTYNY AVLKFLSRDD
     CCTKF