ID   ADD2_CAEEL              Reviewed;         611 AA.
AC   Q20952;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=Adducin-related protein 2;
GN   Name=add-2; ORFNames=F57F5.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Moorthy S., Bennett V.;
RT   "Molecular and functional analysis of the spectrin based membrane skeleton
RT   in Caenorhabditis elegans.";
RL   Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Membrane-cytoskeleton-associated protein that promotes the
CC       assembly of the spectrin-actin network. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cell
CC       membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250};
CC       Cytoplasmic side {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the aldolase class II family. Adducin subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AF166171; AAD49860.1; -; mRNA.
DR   EMBL; Z75953; CAB00100.1; -; Genomic_DNA.
DR   PIR; T22855; T22855.
DR   RefSeq; NP_001041130.1; NM_001047665.3.
DR   AlphaFoldDB; Q20952; -.
DR   SMR; Q20952; -.
DR   BioGRID; 44671; 1.
DR   IntAct; Q20952; 1.
DR   STRING; 6239.F57F5.4a.1; -.
DR   iPTMnet; Q20952; -.
DR   EPD; Q20952; -.
DR   PaxDb; Q20952; -.
DR   PeptideAtlas; Q20952; -.
DR   EnsemblMetazoa; F57F5.4a.1; F57F5.4a.1; WBGene00000073.
DR   GeneID; 179647; -.
DR   KEGG; cel:CELE_F57F5.4; -.
DR   UCSC; F57F5.4a.1; c. elegans.
DR   CTD; 179647; -.
DR   WormBase; F57F5.4a; CE06002; WBGene00000073; add-2.
DR   eggNOG; KOG3699; Eukaryota.
DR   GeneTree; ENSGT00940000168292; -.
DR   HOGENOM; CLU_447074_0_0_1; -.
DR   InParanoid; Q20952; -.
DR   OMA; LERQHSY; -.
DR   OrthoDB; 400524at2759; -.
DR   PhylomeDB; Q20952; -.
DR   Reactome; R-CEL-5223345; Miscellaneous transport and binding events.
DR   Reactome; R-CEL-9013405; RHOD GTPase cycle.
DR   Reactome; R-CEL-9035034; RHOF GTPase cycle.
DR   SignaLink; Q20952; -.
DR   PRO; PR:Q20952; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00000073; Expressed in embryo and 4 other tissues.
DR   ExpressionAtlas; Q20952; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0014069; C:postsynaptic density; IBA:GO_Central.
DR   GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR   Gene3D; 3.40.225.10; -; 1.
DR   InterPro; IPR001303; Aldolase_II/adducin_N.
DR   InterPro; IPR036409; Aldolase_II/adducin_N_sf.
DR   Pfam; PF00596; Aldolase_II; 1.
DR   SMART; SM01007; Aldolase_II; 1.
DR   SUPFAM; SSF53639; SSF53639; 1.
PE   2: Evidence at transcript level;
KW   Actin-binding; Cell membrane; Cytoplasm; Cytoskeleton; Membrane;
KW   Reference proteome.
FT   CHAIN           1..611
FT                   /note="Adducin-related protein 2"
FT                   /id="PRO_0000218541"
SQ   SEQUENCE   611 AA;  68561 MW;  9815707C45CD70D8 CRC64;
     MSDGSDDDTN NDGNYCKNVS YNFLIQRLAE VSNRKCLLLP KKKNRVDYIS IMQTAEFYPE
     LVNSSPPLEP GFTSCEVFVV DKKVDKDTLH LDNFSPYHIG ATRRTLERQH SYFYRVNESG
     NFVPAIKTNG THILRILVSI LGSCPALNRK IYRMVKIESQ NKNCLPSLIV YTFEPGHEIP
     KPNAPAILRR QTSDEIQKIL NIPGTSFSQA HSEAVLNRFY DDLPIRDEAS DQKRARYSIE
     STSSTNNQLN EINSFVVPKF EGRQESEQLF RDVKVEQFEE SAEISINNRA LSPHIQPSKT
     SVVNRPNQQN RKFQNYDMFS AGVISTATVP APMFHPHITP IADLKDDDGY DPEELTQRNK
     LASLYRLVDL FRWSQGIYNH ITVRVSTDPD EILINAFGQL YSEVSASSLI KVDLDGTVID
     GGSTNFGVNQ AGYVLHSAIH NGRPEVKCVV HLHHPSVVAV SAQKCGLLPI SQESMIVGDV
     GYHEYRGILI DEAERALLVR DLGDRNVMIL RNHGFVVCGE SIEHALSLTY HLIIACETQI
     RTVPGGNTDN VHFPAQSAIK QVYKVASQGG GGVNRQNGHV NSMQWKKGEL EWQAYMRQLD
     AQGYVTGNVP N