DMG_SQUAC
ID DMG_SQUAC Reviewed; 246 AA.
AC P36965;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 25-MAY-2022, entry version 48.
DE RecName: Full=Proteolipid protein DM gamma;
OS Squalus acanthias (Spiny dogfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Squalomorphii; Squaliformes; Squalidae; Squalus.
OX NCBI_TaxID=7797;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=8398138; DOI=10.1016/0896-6273(93)90148-k;
RA Kitagawa K., Sinoway M.P., Yang C., Gould R.M., Colman D.R.;
RT "A proteolipid protein gene family: expression in sharks and rays and
RT possible evolution from an ancestral gene encoding a pore-forming
RT polypeptide.";
RL Neuron 11:433-448(1993).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Highly expressed in white matter in myelinating
CC shark brain.
CC -!- SIMILARITY: Belongs to the myelin proteolipid protein family.
CC {ECO:0000305}.
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DR EMBL; U02975; AAC59641.1; -; mRNA.
DR PIR; I51325; I51325.
DR AlphaFoldDB; P36965; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR001614; Myelin_PLP.
DR InterPro; IPR018237; Myelin_PLP_CS.
DR PANTHER; PTHR11683; PTHR11683; 1.
DR Pfam; PF01275; Myelin_PLP; 1.
DR PRINTS; PR00214; MYELINPLP.
DR SMART; SM00002; PLP; 1.
DR PROSITE; PS00575; MYELIN_PLP_1; 1.
DR PROSITE; PS01004; MYELIN_PLP_2; 1.
PE 2: Evidence at transcript level;
KW Membrane; Transmembrane; Transmembrane helix.
FT CHAIN 1..246
FT /note="Proteolipid protein DM gamma"
FT /id="PRO_0000159017"
FT TRANSMEM 19..35
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..222
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 246 AA; 26806 MW; DD87E049563255C3 CRC64;
MGCFECCIKC LGGVPYASLL ATILCFSGVA LFCGCGHVAL TKVERIVQLY FSNNASDHVL
LTDVIQMMHY VIYGVASFSF LYGIILLAEG FYTTSAVKEI HGEFKTTVCG RCISGMSVFL
TYLLGIAWLG VFGFSAVPAF IYYNMWSACQ TISSPPVNLT TVIEEICVDV RQYGIIPWNA
SPGKACGSTL TTICNTSEFD LSYHLFIVAC AGAGATVIAL LIYMMATTYN FAVLKFKSRE
DCCTKF