ID   DMKN_BOVIN              Reviewed;         510 AA.
AC   A2VE23;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Dermokine;
DE   Flags: Precursor;
GN   Name=DMKN;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as a soluble regulator of keratinocyte
CC       differentiation. {ECO:0000305}.
CC   -!- SUBUNIT: Homooligomer. Seems to be able to homodimerize and
CC       homotrimerize (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- PTM: O-glycosylated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the dermokine family. {ECO:0000305}.
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DR   EMBL; BC133532; AAI33533.1; -; mRNA.
DR   RefSeq; NP_001075932.1; NM_001082463.1.
DR   AlphaFoldDB; A2VE23; -.
DR   STRING; 9913.ENSBTAP00000021161; -.
DR   PaxDb; A2VE23; -.
DR   PeptideAtlas; A2VE23; -.
DR   Ensembl; ENSBTAT00000021161; ENSBTAP00000021161; ENSBTAG00000015912.
DR   GeneID; 618159; -.
DR   KEGG; bta:618159; -.
DR   CTD; 93099; -.
DR   VEuPathDB; HostDB:ENSBTAG00000015912; -.
DR   VGNC; VGNC:28107; DMKN.
DR   eggNOG; ENOG502QQ65; Eukaryota.
DR   GeneTree; ENSGT00570000079107; -.
DR   HOGENOM; CLU_045546_1_0_1; -.
DR   InParanoid; A2VE23; -.
DR   OrthoDB; 917254at2759; -.
DR   Proteomes; UP000009136; Chromosome 18.
DR   Bgee; ENSBTAG00000015912; Expressed in zone of skin and 40 other tissues.
DR   ExpressionAtlas; A2VE23; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:1903575; P:cornified envelope assembly; IBA:GO_Central.
DR   InterPro; IPR033541; Dermokine.
DR   PANTHER; PTHR36881; PTHR36881; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000250"
FT   CHAIN           22..510
FT                   /note="Dermokine"
FT                   /id="PRO_0000330763"
FT   REGION          117..362
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        124..179
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        191..329
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        344..362
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   510 AA;  50549 MW;  E6C8668A034FC799 CRC64;
     MKLKGSLACL LLFLLLGSGE ASPLQSGEEN TREEVGEAIG HGVGEALGDV LGEAAIHGIE
     KAIGQGTGKT EGLGIREARD PHLGDALAHK LKEASHALKN TGSEADRQAE NIIGHGVDPA
     HKSWQGTPGS NGAWGTNGQP PSGGHGIPGS QGSSGGPGDT QDQVFSGGSG GSFGANAQGG
     SWGQGGHRGA FNLGANSQGT SPQPGSVRSN NNRNTECTTP PGSGGSSGNS GGSSSSGSST
     NGGGSSGGSN GGSNGSTSSN SGSSNGGGSS NSGGSNGGGS NGGGSSNGGG SNAGSSGSSG
     SSSDTRNSDH GGSSQGYNPS PSSGSRVGSG VRNKPECDNP HVSGGSGGQG QGSSGEGEAV
     SGINTLNSQT SSESFNFDTF WKNFKSKLGF INWDALNKGQ APPPSTRALL YFRRLWEDFK
     HNTPFLNWKV ITEGEDLPSL QKRAGGAGQP GTGWQDAVAG TAKNYNYNQQ GPPAALGGQY
     PAKTPAKGGV TVSSSASRTY PGLLQWVKFW